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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Accumulation of fluconazole in scalp hair.
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Accumulation of fluconazole in scalp hair.

机译：氟康唑在头皮头发中积累。

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The accumulation in scalp hair of the antimycotic triazole, fluconazole, was studied during and after administration. Fluconazole 50 mg was administered to 12 healthy subjects as a single capsule each day for 28 days. The concentration of fluconazole 5 hours after administration was measured in different 1-cm sections of scalp hair at intervals during treatment and for 6 months after the end of treatment. In each section of scalp hair the concentration of fluconazole increased during treatment and was consistently higher than values found in plasma. For example, the mean concentration in the first hair section on day 28, 19.8 micrograms/g, corresponded to a mean penetration ratio relative to plasma of 9.42. During administration, the maximal concentration of fluconazole was found in the first hair section. After cessation of administration, the measured concentrations of fluconazole decreased and greater concentrations were found in the distal hair sections, presumably as a result of hair growth. Fluconazole was detectable, however, in the hair of 9 of the 12 subjects even 6 months after treatment. The mean concentration of fluconazole in hair bulbs on day 28 was 12.1 micrograms/g (n = 6), corresponding to a mean penetration ratio of 5.99. In a second study, fluconazole was administered as a single oral 150-mg capsule per week for 4 weeks to a group of 8 healthy subjects. The mean fluconazole concentration in whole scalp hair 5 hours after the last dose was 3.2 micrograms/g.
机译：在给药期间和给药后研究了抗真菌三唑氟康唑在头皮中的积累。每天将氟康唑50 mg作为单一胶囊给予12位健康受试者，持续28天。在治疗期间的间隔和治疗结束后的6个月内，在头皮头发的不同的1cm区域中，在给药后5小时测量氟康唑的浓度。在头皮头发的每个部分中，氟康唑的浓度在治疗过程中均增加，并且始终高于血浆中的浓度。例如，第28天在第一根毛发部分的平均浓度为19.8微克/克，对应于相对于血浆的平均渗透比为9.42。在给药过程中，在第一根毛发部位发现了氟康唑的最大浓度。停止给药后，氟康唑的测定浓度降低，并且在远侧毛发部分发现了更高的浓度，这可能是由于毛发生长造成的。然而，即使在治疗后6个月，也可以在12名受试者中的9名头发中检出氟康唑。在第28天，氟康唑在毛囊中的平均浓度为12.1微克/克（n = 6），对应于5.99的平均渗透率。在第二项研究中，氟康唑以单次口服150 mg胶囊的形式每周一次给药于8位健康受试者，共4周。最后一剂后5小时，整个头皮头发中的氟康唑平均浓度为3.2微克/克。

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