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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Possible induction of cholinesterase in epileptic patients treated with anticonvulsant drugs: relationship with lipoprotein levels.
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Possible induction of cholinesterase in epileptic patients treated with anticonvulsant drugs: relationship with lipoprotein levels.

机译：抗惊厥药治疗的癫痫患者可能诱发胆碱酯酶：与脂蛋白水平的关系。

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摘要

The effect of enzyme-inducing anticonvulsant drugs on the serum concentrations of lipoproteins has been widely studied. However, there is little agreement between the results with regard to the possible development of a lipoprotein profile related to an increased or decreased cardiovascular risk. It has been suggested that cholinesterase (ChE) could be induced by these drugs, something of undeniable interest as ChE appears to have a relation to the metabolism of lipoproteins. The serum activity of ChE was determined in a group of 90 adult epileptic patients (56 male and 34 female) treated with phenobarbital, phenytoin, and carbamazepine. The liver enzyme induction produced by these drugs was then evaluated by determining serum gamma-glutamyltranspherase activity and urinary excretion of D-glucaric acid. A significant increase of serum ChE (p < 0.005) was found in the group of patients compared to a control group (n = 49) with a similar distribution for age and sex. A significant correlation was found for both male and female patients between ChE and concentrations of triglycerides, phospholipids, cholesterol, low-density lipoprotein (LDL) phospholipids, LDL-cholesterol, and apolipoprotein B (p < 0.01). Similarly, in female patients, ChE had a significant correlation with the total cholesterol/high-density lipoprotein (HDL) cholesterol and LDL-cholesterol/HDL-cholesterol ratios (p < 0.01). The ChE/HDL-cholesterol relationship, which has been proposed as a marker for cardiovascular risk, presented significant correlations with the total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios in patients of both sexes (p < 0.001). In the case of epileptic patients treated with enzyme-inducing anticonvulsant drugs, there may be an association between the possible induction of ChE and the metabolism of lipoproteins containing apolipoprotein B.
机译：广泛研究了诱导酶的抗惊厥药物对血清脂蛋白浓度的影响。但是，关于脂蛋白谱与心血管风险增加或降低有关的可能发展，结果之间几乎没有共识。已经提出胆碱酯酶（ChE）可以被这些药物诱导，这是不可否认的，因为ChE似乎与脂蛋白的代谢有关。在一组接受苯巴比妥，苯妥英钠和卡马西平治疗的90例成人癫痫患者（56例男性和34例女性）中确定了ChE的血清活性。然后通过测定血清γ-谷氨酰转移酶活性和D-葡萄糖酸的尿排泄量来评估由这些药物产生的肝酶诱导作用。与对照组（n = 49）相比，该组患者的血清ChE显着增加（p <0.005），年龄和性别分布相似。在男性和女性患者中，ChE与甘油三酸酯，磷脂，胆固醇，低密度脂蛋白（LDL）磷脂，LDL-胆固醇和载脂蛋白B的浓度之间存在显着相关性（p <0.01）。同样，在女性患者中，ChE与总胆固醇/高密度脂蛋白（HDL）胆固醇和LDL-胆固醇/ HDL-胆固醇比率具有显着相关性（p <0.01）。 ChE / HDL-胆固醇关系已被建议作为心血管风险的标志，与男女双方的总胆固醇/ HDL-胆固醇和LDL-胆固醇/ HDL-胆固醇比率呈显着相关性（p <0.001）。对于使用酶诱导抗惊厥药物治疗的癫痫患者，可能的ChE诱导与含载脂蛋白B的脂蛋白代谢之间可能存在关联。

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