...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Potential benefits of combined N-acetylcysteine and ciprofloxacin therapy in partial biliary obstruction.
【24h】

Potential benefits of combined N-acetylcysteine and ciprofloxacin therapy in partial biliary obstruction.

机译：N-乙酰半胱氨酸联合环丙沙星治疗胆道部分梗阻的潜在益处。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study investigates the potential benefits of antibiotics and N-acetylcysteine (NAC), a mucolytic agent, in patients who are candidates for endoscopic retrograde cholangiopancreatography (ERCP) due to partial bile duct obstruction. In total, 102 patients who had choledocholithiasis and choledochal dilatations by abdominal ultrasonography were included in the study. The patients were divided into placebo and NAC therapy groups. Physiological saline (equal volume with NAC solution) and ciprofloxacin (2 x 200 mg/d intravenously) were administered to the placebo group, and NAC (1800 mg/d intravenously) and ciprofloxacin (2 x 200 mg/d intravenously) were administered to the NAC group. In both groups, treatment protocols were administered for 7 days before ERCP. Total and direct bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), C-reactive protein (CRP), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), white blood cell (WBC) count, and neutrophil percent (NE%) levels were measured before the 7-day treatment protocol. The same measurements were also evaluated before ERCP. In the NAC group, the levels of ALP, GGT, WBC, CRP, and NE% decreased significantly (P < .001), whereas a significant decrease did not occur in the placebo group. The combined usage of NAC and ciprofloxacin can be an alternative therapeutic option until ERCP is performed in partial cholestatic patients.
机译：这项研究调查了由于部分胆管阻塞而接受内镜逆行胰胆管造影术（ERCP）的患者中抗生素和N-乙酰半胱氨酸（NAC）（一种粘液溶解剂）的潜在益处。本研究共纳入102例因腹部超声检查而发生胆总管结石和胆总管扩张的患者。将患者分为安慰剂组和NAC治疗组。安慰剂组服用生理盐水（与NAC溶液等体积）和环丙沙星（静脉注射2 x 200 mg / d），NAC（静脉注射1800 mg / d）和环丙沙星（静脉注射2 x 200 mg / d）给予安慰剂组。 NAC组。两组均在ERCP之前接受了7天的治疗方案。总胆红素，直接胆红素，天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），C反应蛋白（CRP），碱性磷酸酶（ALP），γ-谷氨酰转肽酶（GGT），白细胞（WBC）计数和中性白细胞百分比（NE％）水平在7天治疗方案之前进行了测量。在ERCP之前也评估了相同的测量结果。在NAC组中，ALP，GGT，WBC，CRP和NE％的水平显着降低（P <.001），而在安慰剂组中则没有显着降低。 NAC和环丙沙星的联合使用可以作为替代治疗选择，直到部分胆汁淤积患者进行ERCP。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号