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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Comparison of the behavioral and cardiovascular effects of intranasal and oral d-amphetamine in healthy human subjects.
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Comparison of the behavioral and cardiovascular effects of intranasal and oral d-amphetamine in healthy human subjects.

机译：鼻内和口服d-苯异丙胺对健康人的行为和心血管作用的比较。

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摘要

Recent reports indicate an increase in intranasal use of prescription oral stimulant medication. However, there do not appear to be any published clinical studies that have characterized the behavioral and cardiovascular effects of intranasally administered d-amphetamine, which is commonly prescribed for Attention Deficit Hyperactivity Disorder. In this study, a range of d-amphetamine doses (0, 16, 24, and 32 mg/70 kg) were administered as an intranasal solution delivered using a mucosal atomization device. Equal oral doses were included for comparison. Assessments were conducted before and at regular intervals for 3 hours following drug administration and included self-reported drug-effect questionnaires, cardiovascular indices, a performance task, and 2 measures of impulsivity. d-Amphetamine produced prototypical stimulant effects (eg, increased subject ratings of Stimulated and Like Drug, elevated heart rate and blood pressure, and improved rate and accuracy on the digit symbol substitution task) irrespective of dose, but the onset of these effects was generally earlier following intranasal administration, with significant effects emerging 15 to 30 minutes after intranasal dosing and 45 to 60 minutes after oral dosing. These results demonstrate that intranasal administration of d-amphetamine results in a more rapid onset compared to oral dosing, which could be associated with the popularity of intranasal prescription stimulant use and an enhanced potential for abuse.
机译：最近的报道表明鼻内使用处方口服刺激药物的情况有所增加。但是，似乎没有任何公开的临床研究以鼻内给药的d-苯异丙胺的行为和心血管效应为特征，d-苯丙胺通常用于注意缺陷多动症。在这项研究中，一系列的D-苯丙胺剂量（0、16、24和32 mg / 70 kg）作为鼻腔溶液使用粘膜雾化装置给药。包括相等的口服剂量用于比较。评估在给药前和给药后3个小时内定期进行，包括自我报告的药物作用问卷，心血管指数，一项工作任务和2种冲动测量。不论剂量如何，d-苯丙胺都会产生原型刺激作用（例如，刺激和类似药物的受试者评分增加，心率和血压升高以及数字符号替代任务的改善率和准确性），但这些作用的发作通常是鼻内给药后较早，鼻内给药后15至30分钟和口服给药后45至60分钟出现显着效果。这些结果表明，与口服给药相比，鼻内给予d-苯丙胺导致起效更快，这可能与鼻内处方兴奋剂的普及和滥用的可能性增加有关。

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