Positive control in a 'thorough QT/QTc study'

LiuQ.; CaoY.J.

首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Positive control in a 'thorough QT/QTc study'

【24h】

Positive control in a 'thorough QT/QTc study'

机译：“全面的QT / QTc研究”中的阳性对照

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In a recent issue of the Journal of Clinical Pharmacology, Chatterjee et al1 reported the first "thorough QT/QTc study" on GLP-1 analog liraglu-tide. Although the study provided important scientific information on the effects of liraglutide on the QT/QTc intervals, treatment of the positive control deserves additional discussion.In this study, the authors claimed that the upper bound of the 95% one-sided confidence intervals for the maximum mean difference of time-matched, baseline-subtracted QTc values between the positive control moxifloxacin and placebo, which was larger than 10 ms, confirmed the internal validity of the study to detect prolongation of the QTc interval.

机译：在最近一期的《临床药理学杂志》上，Chatterjee等人1报道了有关GLP-1类似物liraglu-tide的第一个“全面QT / QTc研究”。尽管该研究提供了有关利拉鲁肽对QT / QTc间隔的影响的重要科学信息，但阳性对照的治疗值得进一步讨论。在本研究中，作者声称95％单侧置信区间的上限阳性对照莫西沙星与安慰剂之间时间匹配的，减去基线的QTc值的最大平均差大于10 ms，这证实了该研究检测QTc间隔延长的内部有效性。

著录项

来源
《The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology》 |2012年第1期|共2页
作者
LiuQ.; CaoY.J.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词

相似文献

外文文献
中文文献
专利

1. Absence of QTc prolongation with domperidone: A randomized, double-blind, placebo- and positive-controlled thorough QT/QTc study in healthy volunteers [J] . Clinical pharmacology in drug development . 2015,第1期

机译：多潘立酮不延长QTc：在健康志愿者中进行的一项随机，双盲，安慰剂和阳性对照的全面QT / QTc研究
2. Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects [J] . Darpo Borje, Xue Hongqi, Tanaka S. Ken, Antimicrobial agents and chemotherapy. . 2019,第10期

机译：随机，双盲，安慰剂，安慰剂和正控制的交叉研究omaDitycline对健康受试者Qt / QTC间隔的影响
3. Effects of Nemonoxacin on Thorough ECG QT/QTc Interval: A Randomized, Placebo- and Positive-controlled Crossover Study in Healthy Chinese Adults [J] . Zhao Caiyun, Lv Yuan, Li Xiangyan, Clinical therapeutics . 2018,第6期

机译：Nemonoxacin对彻底ECG QT / QTC间隔的影响：健康中国成人的随机，安慰剂和积极控制的交叉研究
4. Comparing the relationship between QT/RR slope and basal QTc in LQT1 patients and healthy subjects [C] . Halamek Josef, Jurak Pavel, Leinveber Pavel, Computing in Cardiology Conference . 2013

机译：比较LQT1患者和健康受试者的QT / RR斜率与基础QTc之间的关系
5. Novel statistical approaches to assessing the risk of QT prolongation and sample size calculations in 'thorough QT/QTc studies'. [D] . Anand, Suraj P. 2009

机译：评估“全面QT / QTc研究”中QT延长风险和样本量计算的新颖统计方法。
6. Absence of QTc Prolongation with Domperidone: A Randomized Double-Blind Placebo- and Positive-Controlled Thorough QT/QTc Study in Healthy Volunteers [O] . Jeike Biewenga, Chi Keung, Bhavna Solanki, -1

机译：多潘立酮缺乏QTc延长：健康志愿者中一项随机双盲安慰剂和阳性对照的全面QT / QTc研究
7. Absence of QTc prolongation with Domperidone: A randomized, double-blind, placebo- and positive-controlled Thorough QT/QTc study in healthy volunteers [O] . Biewenga, Jeike, Keung, Chi, Solanki, Bhavna, 2015

机译：多潘立酮不延长QTc寿命：一项针对健康志愿者的随机，双盲，安慰剂对照和阳性对照的彻底QT / QTc研究

Positive control in a 'thorough QT/QTc study'

摘要

著录项

相似文献

相关主题

期刊订阅