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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Buprenorphine pharmacokinetics: relative bioavailability of sublingual tablet and liquid formulations.
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Buprenorphine pharmacokinetics: relative bioavailability of sublingual tablet and liquid formulations.

机译：丁丙诺啡药代动力学：舌下片剂和液体制剂的相对生物利用度。

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摘要

Buprenorphine is an effective new treatment for opiate dependence. This study compared the bioavailability of buprenorphine from a tablet to that from a reference solution. Six men experienced with, but not dependent on, opiates (DSM-III-R) were each administered 7.7 mg of buprenorphine in liquid form and 8 mg in tablet form 1 week apart in a balanced crossover design. Plasma levels were measured by electron capture capillary gas chromatography (GC), and concentration-time curves were constructed. Pharmacokinetic data were analyzed by analysis of variance. The bioavailability from the tablet was approximately 50% that from the liquid and was not affected by saliva pH. Lower bioavailability from the tablet may be due to slow dissolution.
机译：丁丙诺啡是一种有效的鸦片依赖新疗法。这项研究比较了片剂中丁丙诺啡的生物利用度与参考溶液的生物利用度。六名经历但不依赖于阿片类药物（DSM-III-R）的男性在平衡的交叉设计中，每隔1周分别服用7.7 mg液体丁丙诺啡和8 mg片剂。通过电子捕获毛细管气相色谱法（GC）测量血浆水平，并绘制浓度-时间曲线。通过方差分析来分析药代动力学数据。片剂的生物利用度约为液体的生物利用度的50％，不受唾液pH值的影响。平板电脑的生物利用度较低可能是由于溶解缓慢所致。

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