Metronidazole-induced encephalopathy: a case report and review of the literature.

Bottenberg MM; Hegge KA; Eastman DK; Kumar R

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Metronidazole-induced encephalopathy: a case report and review of the literature.

机译：甲硝唑诱发的脑病：一例病例报告并复习文献。

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Metronidazole is a synthetic nitroimidazole antibiotic that is active against various protozoans as well as most Gram-negative and Gram-positive anaerobic bacteria. Although the mechanism of action for metronidazole is not entirely known, it is believed to exhibit cytotoxic effects by damaging DNA, resulting in inhibition of protein synthesis and ultimately cell death. Since its original use for the treatment of infections caused by Trichomonas vaginalis nearly 5 decades ago, metronidazole has proven useful in the treatment of a variety of conditions, including bacterial vaginosis, Helicobacter pylori infections, giardiasis, amoebiasis, and Clostridium difficile colitis.

机译：甲硝唑是一种合成的硝基咪唑抗生素，对多种原生动物以及大多数革兰氏阴性和革兰氏阳性厌氧菌具有活性。尽管甲硝唑的作用机理尚不完全清楚，但据信会通过破坏DNA表现出细胞毒性作用，从而抑制蛋白质合成并最终导致细胞死亡。自将近5年前甲硝唑最初用于治疗阴道毛滴虫引起的感染以来，已证明可用于治疗多种疾病，包括细菌性阴道病，幽门螺杆菌感染，贾第鞭毛虫病，阿米巴病和艰难梭菌结肠炎。

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《The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology》 |2011年第1期|共5页
作者
Bottenberg MM; Hegge KA; Eastman DK; Kumar R;
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正文语种 eng
中图分类药理学;
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Metronidazole-induced encephalopathy: a case report and review of the literature.

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