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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine
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Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine

机译：法莫替丁预防抗血小板药物引起的胃粘膜损伤

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摘要

Anti-platelet drug-induced gastric mucosal injury correlates with intragastric pH. Our aim was to investigate prophylaxis effects of famotidine, one of the representative histamine-2 receptor antagonists (H2RA), on gastric mucosal injury induced by dual therapy with low-dose aspirin and clopidogrel in relation to Helicobacter pylori (H. pylori) infection and CYP2C19 genotypes. This study was conducted for 20 healthy Japanese volunteers (10 H. pylori-positive and 10-negative subjects) with 100mg aspirin plus 75mg clopidogrel (AC) once-daily dosing and AC plus 20mg famotidine twice-daily dosing (ACH). Mucosal injury was endoscopically assessed on day 3 and 7 and 24-hour intragastric pH and antiplatelet-function test was performed on day 7. Median pH in ACH was similar between CYP2C19 extensive metabolizer (EM) and intermediate metabolizer (IM)/poor metabolizer (PM) and was significantly higher in H. pylori-positive than negative subjects (P<.05). Mucosal injury with ACH significantly decreased in both day 3 and 7 compared with AC, irrespective with H. pylori and CYP2C19 genotypes (P<.05). Although antiplatelet effect of clopidogrel in EM was significantly higher than that in IM/PM, the additional famotidine did not affect the effect. Anti-platelet drug-induced gastric injury was alleviated by famotidine without attenuation of anti-platelet functions irrespective of H. pylori and CYP2C19 genotypes.
机译：抗血小板药物引起的胃粘膜损伤与胃内pH相关。我们的目的是研究法莫替丁（一种代表性的组胺2受体拮抗剂（H2RA））对低剂量阿司匹林和氯吡格雷双重疗法引起的胃黏膜损伤与幽门螺杆菌感染和幽门螺杆菌感染的预防作用。 CYP2C19基因型。这项研究是针对20名健康的日本志愿者（10例幽门螺杆菌阳性和10例阴性受试者）进行的，一次服用100mg阿司匹林加75mg氯吡格雷（AC），一次服用AC + 20mg法莫替丁，每天服用两次（ACH）。在第3天和第7天通过内窥镜评估粘膜损伤，并在第7天进行24小时胃内pH值测试，并在第7天进行抗血小板功能测试。CYP2C19广泛代谢物（EM）和中间代谢物（IM）/不良代谢物（ PM），幽门螺杆菌阳性者显着高于阴性者（P <.05）。与幽门螺杆菌和CYP2C19基因型无关，与AC相比，ACH的粘膜损伤在第3天和第7天均显着降低（P <.05）。尽管氯吡格雷在EM中的抗血小板作用明显高于IM / PM，但额外的法莫替丁不会影响该作用。法莫替丁可减轻抗血小板药物引起的胃损伤，而不会降低幽门螺杆菌和CYP2C19基因型，从而不会削弱抗血小板功能。

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