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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Effects of cholestyramine on vitamin E levels in patients treated with statins.
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Effects of cholestyramine on vitamin E levels in patients treated with statins.

机译:消胆胺对他汀类药物治疗的患者维生素E水平的影响。

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The aim of this study was to investigate the effects of cholestyramine in combination with statins on vitamin E levels and their concentration related to LDL-cholesterol (LDL-C) in patients with hyperlipidemia. In an open-label, randomized study of 25 patients with elevated LDL-C, 12 received cholestyramine (12 g/d) in addition to chronic statin therapy, which had been started at least 8 weeks prior to the study in all patients. At the start and end of the 12-week study period, vitamin E concentrations were measured by high-performance liquid chromatography and cholesterol and triglycerides enzymatically in all patients. Vitamin E levels remained virtually unchanged within normal range before (11.90 +/- 0.71 mg/l) and after 12 weeks (11.69 +/- 0.82 mg/l) of concomitant therapy with cholestyramine. However, the ratio of vitamin E/LDL-C increased from 7.48 +/- 0.56 to 8.58 +/- 0.75 (x 10(-2)) (p < 0.09) in the cholestyramine group but not in the control group. LDL-C concentrations decreased from 162.00 +/- 5.98 to 144.33 +/- 12.48 mg/dl. The authors conclude that cholestyramine 12 g/d given for 12 weeks in addition to chronic statin therapy did not lower vitamin E levels in hyperlipemic patients. However, antioxidant status (vitamin E/LDL-C ratio) seems to be improved by a cholestyramine-associated LDL-C decrease.
机译:这项研究的目的是研究胆甾醇胺联合他汀类药物对高脂血症患者维生素E水平及其与LDL-胆固醇(LDL-C)相关的浓度的影响。在一项针对25名LDL-C升高患者的开放标签随机研究中,除慢性他汀类药物疗法外,还有12名患者接受了胆甾胺(12 g / d)治疗,该疗法已在所有患者研究前至少8周开始。在为期12周的研究期开始和结束时,通过高效液相色谱法测定所有患者的维生素E浓度,并通过酶法测定胆固醇和甘油三酸酯。胆甾胺的同时治疗前(11.90 +/- 0.71 mg / l)和12周(11.69 +/- 0.82 mg / l)的正常范围内,维生素E水平基本保持不变。然而,胆甾醇胺组的维生素E / LDL-C的比例从7.48 +/- 0.56增加到8.58 +/- 0.75(x 10(-2))(p <0.09),而对照组没有。 LDL-C浓度从162.00 +/- 5.98降至144.33 +/- 12.48 mg / dl。作者得出的结论是,除了慢性他汀类药物治疗外,连续12周每天服用12克胆甾醇胺并不能降低高血脂患者的维生素E水平。然而,胆甾醇胺相关的LDL-C降低似乎改善了抗氧化剂状态(维生素E / LDL-C比)。

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