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首页> 外文期刊>The journal of clinical psychiatry >Risperidone side effects.
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Risperidone side effects.

机译：利培酮的副作用。

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摘要

The overall effectiveness of traditional antipsychotics has been hindered by their extrapyramidal side effects, which contribute to noncompliance and relapse in patients with schizophrenia. The side effects associated with traditional antipsychotic treatment are generally minimal in patients who take risperidone, a combined 5-HT2/D2 antagonist, but the literature is sparse on adverse events among the newer atypical antipsychotics. Risperidone is associated with relatively few motor side effects compared with the traditional antipsychotics, and weight gain is less likely with risperidone than with either clozapine or olanzapine. While increased prolactin levels have been reported in patients taking risperidone, little correlation has been found between prolactin levels and adverse events. As antipsychotic treatment options expand to include the new agents, it is important for clinicians to anticipate side effects and to query patients about specific adverse events.
机译：传统的抗精神病药的总体有效性已受到其锥体束外副作用的阻碍，这些副作用导致精神分裂症患者不依从和复发。与传统抗精神病药物治疗相关的副作用通常在服用利培酮（一种联合使用的5-HT2 / D2拮抗剂）的患者中极少发生，但文献报道在新型非典型抗精神病药物中发生的不良事件很少。与传统抗精神病药相比，利培酮具有相对较少的运动副作用，并且与氯氮平或奥氮平相比，利培酮的体重增加可能性较小。虽然已报告服用利培酮的患者催乳素水平升高，但催乳素水平与不良事件之间几乎没有相关性。随着抗精神病药物的治疗方案扩展到包括新药在内，对临床医生而言重要的是预见副作用并向患者询问具体的不良事件。

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