...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Chronic depression and comorbid personality disorders: response to sertraline versus imipramine.
【24h】

Chronic depression and comorbid personality disorders: response to sertraline versus imipramine.

机译：慢性抑郁症和合并症人格障碍：对舍曲林与丙咪嗪的反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Chronic subtypes of depression appear to be associated with high rates of Axis II personality disorder comorbidity. Few studies, though, have systematically examined the clinical correlates of Axis II personality disorder comorbidity or its effect on treatment response or time to response. METHOD: 635 patients diagnosed with DSM-III-R chronic major depression or "double depression" (dysthymia with concurrent major depression) were randomized to 12 weeks of double-blind treatment with either sertraline or imipramine between February 1993 and December 1994. Axis II diagnoses were made using the personality disorders version of the DSM-III-R Structured Clinical Interview. The effect of study treatment was measured utilizing the Hamilton Rating Scale for Depression and the Clinical Global Impressions scale. RESULTS: Forty-six percent of patients met criteria for at least 1 comorbid Axis II personality disorder, with cluster C diagnoses being the most frequent at 39%; 21% met criteria for at least 2 Axis II personality disorders. A cluster C diagnosis was associated with significantly higher rates of early-onset depression (before age 21; 47% vs. 32% for no cluster C; p =.005) and comorbid anxiety disorder (34% vs. 18% for no cluster C; p <.001). Overall, the presence of Axis II personality disorder comorbidity had minimal-to-no effect on the ability to achieve either an antidepressant response or remission and had inconsistent effects on time to response. The presence of Axis II personality disorder comorbidity did not appear to reduce functional and quality-of-life improvements among patients responding to acute treatment with sertraline or imipramine. CONCLUSION: In this treatment sample, rates of Axis II personality disorder comorbidity were substantial in patients suffering from chronic forms of depression. Axis II personality disorder comorbidity did not appear to diminish symptomatic response to acute treatment or associated improvement in functioning and quality of life.
机译：背景：抑郁症的慢性亚型似乎与第二轴人格障碍合并症的高发病率有关。但是，很少有研究系统地检查Axis II型人格障碍合并症的临床相关性或其对治疗反应或反应时间的影响。方法：在1993年2月至1994年12月之间，将635例诊断为DSM-III-R慢性重度抑郁或“双重抑郁”（重度抑郁症并发重度抑郁）的患者随机分为12周，接受舍曲林或丙米拉明​​双盲治疗。使用DSM-III-R结构性临床访谈的人格障碍版本进行诊断。研究治疗的效果是使用汉密尔顿抑郁量表和临床总体印象量表来衡量的。结果：46％的患者符合至少1种合并症的Axis II型人格障碍的标准，C组诊断最常见，为39％; 21％的人符合至少2种Axis II人格障碍的标准。 C组诊断与早期抑郁症的发病率显着较高（21岁之前; 47％vs. 32组无C组; p = .005）和合并症焦虑症（34％vs. 18％无组） C; p <.001）。总体而言，Axis II型人格障碍合并症的存在对实现抗抑郁反应或缓解能力的影响微乎其微或没有影响，并且对响应时间的影响不一致。在对舍曲林或丙咪嗪进行急性治疗的患者中，Axis II型人格障碍合并症的出现似乎并未降低其功能和生活质量的改善。结论：在该治疗样本中，患有慢性抑郁症的患者中的轴II型人格障碍合并症发生率很高。轴II型人格障碍合并症似乎并未减少对急性治疗的症状反应或功能和生活质量的相关改善。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号