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首页> 外文期刊>The journal of clinical psychiatry >Nonhuman Primate Studies of Fear, Anxiety, and Temperament and the Role of Benzodiazepine Receptors and GABA Systems.
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Nonhuman Primate Studies of Fear, Anxiety, and Temperament and the Role of Benzodiazepine Receptors and GABA Systems.

机译：非人类灵长类动物对恐惧，焦虑和气质的研究以及苯二氮卓受体和GABA系统的作用。

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Studies of nonhuman primate models have been useful in defining anxious temperament as an individual's stable set of physiologic and behavioral responses and in providing insights regarding human anxiety. Anxious temperament in rhesus monkeys (Macaca mulatta) is marked by excessive anxiety, exaggerated defensive behavioral responses, extreme asymmetric right frontal brain electrical activity, and elevated cerebrospinal fluid levels of corticotropin-releasing hormone and plasma cortisol. In the human brain, extreme asymmetric right frontal activation is likewise associated with negative affect and anxious disposition. Our studies of infant rhesus monkeys using the human intruder paradigm allow us to investigate individual differences in fear-related defensive behavioral responses and suggest that responses to threatening stimuli are mediated by gamma-aminobutyric acid and benzodiazepine receptors. Ongoing studies with nonhuman primates in our laboratory are further examining the neurochemistry underlying individual differences in anxious temperament. We believe that these studies will provide insights into the adaptive and maladaptive responses of humans as they relate to psychopathology as associated with anxiety.
机译：对非人类灵长类动物模型的研究可用于将焦虑气质定义为个人稳定的生理和行为反应集，并提供有关人类焦虑的见解。恒河猴（猕猴）的焦虑性情表现为过度焦虑，夸张的防御行为反应，极不对称的右额脑电活动以及促肾上腺皮质激素释放激素和血浆皮质醇水平升高。在人脑中，极端的不对称右额叶激活同样会带来负面影响和焦虑情绪。我们使用人类入侵者范式对恒河猴进行的研究使我们能够研究与恐惧相关的防御行为反应的个体差异，并表明对威胁性刺激的反应是由γ-氨基丁酸和苯并二氮杂receptor受体介导的。在我们实验室中正在进行的有关非人类灵长类动物的研究正在进一步研究焦虑气质个体差异背后的神经化学。我们相信，这些研究将为人们提供与人类与焦虑有关的心理病理学相关的适应性和适应不良反应的见识。

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