...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Structural and functional brain changes in posttraumatic stress disorder.
【24h】

Structural and functional brain changes in posttraumatic stress disorder.

机译：创伤后应激障碍的大脑结构和功能改变。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Posttraumatic stress disorder (PTSD) is a highly disabling condition that is associated with intrusive recollections of a traumatic event, hyperarousal, avoidance of clues associated with the trauma, and psychological numbing. The field of neuroimaging has made tremendous advances in the past decade and has contributed greatly to our understanding of the physiology of fear and the pathophysiology of PTSD. Neuroimaging studies have demonstrated significant neurobiologic changes in PTSD. There appear to be 3 areas of the brain that are different in patients with PTSD compared with those in control subjects: the hippocampus, the amygdala, and the medial frontal cortex. The amygdala appears to be hyperreactive to trauma-related stimuli. The hallmark symptoms of PTSD, including exaggerated startle response and flashbacks, may be related to a failure of higher brain regions (i.e., the hippocampus and the medial frontal cortex) to dampen the exaggerated symptoms of arousal and distress that are mediated through the amygdala in response to reminders of the traumatic event. The findings of structural and functional neuroimaging studies of PTSD are reviewed as they relate to our current understanding of the pathophysiology of this disorder.
机译：创伤后应激障碍（PTSD）是一种高度致残的疾病，与创伤事件的侵入性回忆，过度兴奋，避免与创伤有关的线索以及心理麻木有关。在过去的十年中，神经影像学领域取得了巨大进步，并为我们对恐惧生理学和PTSD的病理生理学的理解做出了巨大贡献。神经影像学研究已证明PTSD有重大的神经生物学改变。与对照组相比，PTSD患者的大脑有3个区域是不同的：海马，杏仁核和额叶内侧皮层。杏仁核似乎对与创伤有关的刺激反应过度。 PTSD的标志性症状，包括夸张的惊吓反应和反跳，可能与较高的大脑区域（即海马和额叶内侧皮层）的衰竭无法缓解通过杏仁核介导的唤醒和困扰的夸大症状有关。回应创伤事件的提醒。对PTSD的结构和功能性神经影像学研究的发现进行了综述，因为它们与我们目前对该疾病的病理生理学的了解有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号