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首页> 外文期刊>The journal of clinical psychiatry >One-year follow-up after successful ECT: a naturalistic study in depressed inpatients.
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One-year follow-up after successful ECT: a naturalistic study in depressed inpatients.

机译：ECT成功后的一年随访：对抑郁症患者的一项自然主义研究。

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BACKGROUND: The aim of this study is to examine both long-term efficacy of electroconvulsive therapy (ECT) and the predictive value of adequate pre-ECT pharmacotherapy and the presence of delusions in relation to post-ECT relapse in patients who suffered from DSM-III-R major depression. METHOD: Forty responders (a decrease in Hamilton Rating Scale for Depression score > or = 50%) to ECT were followed for 1 year, the majority (N = 28) prospectively and the remainder (N = 12) retrospectively. Relapse was defined as readmission, an obvious decline in social functioning, or a change of antidepressant medication caused by a clear worsening of depressive symptoms. RESULTS: Both 6- and 12-month post-ECT relapse was significantly lower in patients with delusional depression compared with nondelusional patients: 3/24 (12%) versus 8/15 (53%) and 5/24 (21%) versus 11/15 (73%), respectively. Relapse rates for the whole sample were 11/39 (28%) at 6 months and 16/39 (41%) at 12 months. Regarding the impact of adequate pre-ECT antidepressant trials on relapse, our data are inconclusive, because only a few patients did not receive adequate pharmacotherapy prior to ECT. CONCLUSION: The remarkable finding of the present study is the favorable 1-year outcome for patients with delusional depression. The relapse rate for patients adequately pretreated with anti-depressants (45% over 1 year) is somewhat more favorable than expected.
机译：背景：本研究的目的是检查电痉挛疗法（ECT）的长期疗效，充分的ECT前ECT药物疗法的预测价值以及与DSM-D患儿ECT复发有关的妄想III-R大抑郁症。方法：对ECT的40名响应者（抑郁抑郁评分汉密尔顿评分量表的降低>或= 50％）进行了1年的随访，其中大多数（N = 28）为前瞻性，其余（N = 12）为回顾性研究。复发定义为再入院，社交功能明显下降或抑郁症状明显加重引起的抗抑郁药物改变。结果：与非妄想患者相比，妄想抑郁患者的ECT术后6个月和12个月复发率均显着降低：3/24（12％）对8/15（53％）和5/24（21％）对11/15（73％）。整个样本的复发率在6个月时为11/39（28％），在12个月时为16/39（41％）。关于充分的ECT前抗抑郁试验对复发的影响，我们的数据尚无定论，因为只有少数患者在ECT之前未接受足够的药物治疗。结论：本研究的显着发现是妄想性抑郁症患者的1年预后良好。接受抗抑郁药充分治疗的患者（一年内45％）的复发率比预期的要好。

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