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首页> 外文期刊>The journal of clinical psychiatry >High-dose olanzapine and prolactin levels.
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High-dose olanzapine and prolactin levels.

机译：大剂量奥氮平和催乳素水平。

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BACKGROUND: This study evaluates whether high-dose olanzapine is associated with elevation of serum prolactin levels. METHOD: Twenty-four patients taking daily doses of olanzapine of 20, 25, 30, and 40 mg for DSM-IV schizophrenia or schizoaffective disorder had serum prolactin levels measured. The patients were all from one author's (J.L.K.'s) clinical practice. The mean duration of olanzapine therapy was 15.3 months at a dose of at least 20 mg/day. Data were gathered in 2000 and 2001. RESULTS: There was no significant correlation between olanzapine dose and prolactin level (Pearson product moment correlation coefficient = 0.09). No significant differences were found between mean prolactin values in each dose group. CONCLUSION: There was no significant elevation of prolactin with higher doses of olanzapine. Thus, preliminary evidence suggests that using higher doses of olanzapine is generally safe with regard to prolactin levels.
机译：背景：本研究评估大剂量奥氮平是否与血清催乳素水平升高有关。方法：二十四例每日服用20、25、30和40毫克奥氮平的DSM-IV精神分裂症或精神分裂症患者的血清催乳素水平被测定。患者全部来自一位作者（J.L.K.）的临床实践。奥氮平治疗的平均持续时间为15.3个月，每天至少20 mg。结果收集于2000年和2001年。结果：奥氮平剂量与催乳素水平之间无显着相关性（皮尔森乘积矩相关系数= 0.09）。在每个剂量组中的平均催乳素值之间没有发现显着差异。结论：高剂量的奥氮平无明显增加催乳素水平。因此，初步证据表明，就催乳素水平而言，使用更高剂量的奥氮平通常是安全的。

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