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首页> 外文期刊>The journal of clinical psychiatry >Changes in Serum Interleukin-2, -6, and -8 Levels Before and During Treatment With Risperidone and Haloperidol: Relationship to Outcome in Schizophrenia.
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Changes in Serum Interleukin-2, -6, and -8 Levels Before and During Treatment With Risperidone and Haloperidol: Relationship to Outcome in Schizophrenia.

机译：利培酮和氟哌啶醇治疗之前和期间血清白细胞介素2，-6和-8水平的变化：与精神分裂症预后的关系。

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BACKGROUND: Many studies have indicated that immune cytokines may be involved in the pathophysiology of schizophrenia. Recently, there have been reports that typical and atypical antipsychotic drugs may influence the levels of cytokines or cytokine receptors. The aim of this study was to compare the effect of typical and atypical antipsychotic drugs on serum interleukin-2 (IL-2), interleukin-6 (IL-6), and interleukin-8 (IL-8) and to investigate the relationship between the changes in cytokines and the therapeutic outcome in schizophrenia. METHOD: From April 1996 to August 1997, seventy-eight inpatients with a diagnosis of chronic schizophrenia (DSM-III-R) were randomly assigned to 12 weeks of treatment with 6 mg/day of risperidone or 20 mg/day of haloperidol. Clinical efficacy was determined using the Positive and Negative Syndrome Scale. Serum IL-2 was assayed by radioimmunometric assay, and serum IL-6 and IL-8 concentrations were measured by quantitative enzyme-linked immunosorbent assay in patients and 30 sex- and age-matched normal subjects. RESULTS: Both risperidone and haloperidol reduced the elevated serum IL-2 concentrations in schizophrenia, and no significant difference was noted in the reduction of serum IL-2 concentrations between risperidone and haloperidol treatment. Neither risperidone nor haloperidol showed significant influence on the higher serum IL-6 or IL-8 concentrations in schizophrenia. Correlations between serum IL-2 or IL-8 concentrations at baseline and the therapeutic outcome were observed, demonstrating that patients presenting with low concentrations of serum IL-2 or IL-8 at baseline showed greater improvement and patients presenting with higher serum IL-2 or IL-8 concentrations at baseline showed less improvement after treatment. CONCLUSIONS: Both typical and atypical anti-psychotic drugs may at least partially normalize abnormal immune alterations in schizophrenia. Some immune parameters at baseline may be useful for predicting the neuroleptic response of schizophrenic patients.
机译：背景：许多研究表明，免疫细胞因子可能与精神分裂症的病理生理有关。最近，有报道说典型的和非典型的抗精神病药可能会影响细胞因子或细胞因子受体的水平。这项研究的目的是比较典型和非典型抗精神病药对血清白介素2（IL-2），白介素6（IL-6）和白介素8（IL-8）的作用，并研究其关系和精神分裂症的治疗结果之间的关系。方法：从1996年4月至1997年8月，将78位诊断为慢性精神分裂症（DSM-III-R）的住院患者随机分配为12周治疗，分别使用6 mg /天的利培酮或20 mg /天的氟哌啶醇治疗。使用阳性和阴性综合征量表确定临床疗效。通过放射免疫测定法测定血清IL-2，并通过定量酶联免疫吸附测定法测定患者以及30名性别和年龄匹配的正常受试者的血清IL-6和IL-8浓度。结果：利培酮和氟哌啶醇均可降低精神分裂症患者血清IL-2的升高浓度，利培酮和氟哌啶醇治疗之间的血清IL-2浓度降低无明显差异。利培酮和氟哌啶醇均未对精神分裂症中较高的血清IL-6或IL-8浓度显示显着影响。观察到基线时血清IL-2或IL-8浓度与治疗结果之间的相关性，表明基线时血清IL-2或IL-8浓度低的患者表现出更大的改善，而血清IL-2较高的患者或基线时IL-8浓度显示治疗后改善较少。结论：典型的和非典型的抗精神病药均可至少部分使精神分裂症的异常免疫改变正常化。基线时的一些免疫参数可能有助于预测精神分裂症患者的神经安定反应。

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