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首页> 外文期刊>The journal of clinical psychiatry >Prevalence of Hyperprolactinemia in Schizophrenia: Association With Typical and Atypical Antipsychotic Treatment.
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Prevalence of Hyperprolactinemia in Schizophrenia: Association With Typical and Atypical Antipsychotic Treatment.

机译：精神分裂症高泌乳素血症的患病率：与典型和非典型抗精神病药物治疗的关联。

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OBJECTIVE: To evaluate the prevalence and severity of hyperprolactinemia among a large sample of patients with schizophrenia and related psychotic disorders treated with typical and atypical antipsychotic medications. METHOD: Three electronic databases (general medical, psychiatric, and pharmacologic) containing the census data from November 2002 through March 2003 for a state-funded, inpatient hospital serving the chronically mentally ill were merged (N = 470). This database was purged of patient names, while the unique hospital identification number and demographic variables in each record were retained. These records were then screened to exclude patients with medications (except neuroleptics) or medical conditions known to elevate or suppress prolactin, leaving an overall sample (N = 422) in which to evaluate the prevalence of hyperprolactinemia. The sample was composed of patients with DSM-IV schizophrenia (N = 213), other related psychotic disorders (N = 131), mood disorders (N = 44), and other disorders (N = 34). RESULTS: For the overall sample (N = 422), which combined men and women, the mean serum prolactin level was 41.5 ng/mL; 290 of 422 patients were above the normal range. For women (N = 133), the mean serum prolactin level was 57.9 ng/mL, and 67% had levels above normal. For men (N = 289), the mean level was 33.9 ng/mL, with a 70% prevalence of hyperprolactinemia. While age did not influence the prevalence of elevated prolactin among men, age (reflecting reproductive status) was a significant variable in women; older age was associated with lower prolactin levels. For the study sample, a highly significant correlation was observed between neuroleptic dose (chlorpromazine equivalent) and serum prolactin level; however, this relationship was not determined on a medication-by-medication basis. Medications known to elevate prolactin were associated with higher prevalence rates of hyperprolactinemia, and "prolactin-sparing" medications had lower prevalence rates. However, when they were used in combination, the prolactin-elevating medication overwhelmed the effects of prolactin-sparing medication. CONCLUSIONS: This study suggested that neuroleptic treatment of schizophrenia is strongly associated with hyperprolactinemia and showed important differences between prolactin-sparing and prolactin-elevating medications.
机译：目的：评估大量使用典型和非典型抗精神病药物治疗的精神分裂症及相关精神病患者的高泌乳素血症的发生率和严重程度。方法：合并了三个电子数据库（普通医学，精神病学和药理学数据库），该数据库包含2002年11月至2003年3月期间由国家资助的住院治疗慢性精神病患者的普查数据（N = 470）。该数据库清除了患者姓名，同时保留了每个记录中唯一的医院识别号和人口统计变量。然后筛选这些记录，以排除患有药物（除精神安定剂外）或已知会升高或抑制催乳素的医疗状况的患者，剩下的全部样本（N = 422）用于评估高泌乳素血症的患病率。该样本由患有DSM-IV精神分裂症（N = 213），其他相关精神病（N = 131），情绪障碍（N = 44）和其他疾病（N = 34）的患者组成。结果：总共样本（N = 422），包括男性和女性，平均血清催乳素水平为41.5 ng / mL。 422名患者中有290名超出正常范围。女性（N = 133）的平均血清催乳素水平为57.9 ng / mL，其中67％的血清催乳素水平高于正常水平。对于男性（N = 289），平均水平为33.9 ng / mL，高泌乳素血症的患病率为70％。尽管年龄不影响男性催乳素升高的患病率，但年龄（反映生殖状态）是女性的重要变量;老年人与催乳素水平降低有关。对于研究样本，在精神抑制药剂量（氯丙嗪当量）与血清催乳素水平之间观察到高度显着的相关性。但是，这种关系不是基于逐药确定的。已知能提高催乳激素水平的药物与高催乳激素血症的患病率相关，而“催乳激素节约型”药物的患病率较低。然而，当将它们组合使用时，增加催乳素的药物不但会减少催乳素的药物的作用。结论：这项研究表明精神分裂症的精神抑制药治疗与高催乳素血症密切相关，并且显示出减少催乳素的药物和增加催乳素的药物之间存在重要差异。

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