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首页> 外文期刊>The journal of clinical psychiatry >Treatment of postpartum depression, part 1: a critical review of biological interventions.
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Treatment of postpartum depression, part 1: a critical review of biological interventions.

机译：产后抑郁症的治疗，第1部分：对生物学干预措施的严格审查。

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BACKGROUND: While postpartum depression is a major health issue for many women from diverse cultures, this affective condition often remains undiagnosed and untreated. The objective of this article is to critically review the literature to determine the current state of scientific knowledge related to the treatment of postpartum depression from a biological perspective. METHOD: Databases searched for this review included MEDLINE, PubMed, CINAHL, PsycINFO, EMBASE, ProQuest, the Cochrane Library, and the WHO Reproductive Health Library from 1966 to 2003. The search terms used were postpartum/ postnatal depression and randomized controlled/ clinical trials in various combinations. Published peer-reviewed articles in English from 1990 to 2003 were chosen for review, although select earlier studies were also included based on good methodological quality and/or the absence of more recent work. The criteria used to evaluate the interventions were based on the standardized methodology developed by the U.S. Preventive Services Task Force and the Canadian Task Force on Preventive Health Care. RESULTS: Nine studies that met study criteria were examined. The interventions studied included antidepressant medication, estrogen therapy, critically timed sleep deprivation, and bright light therapy. Although some of these interventions have been better studied for depression unrelated to childbirth, methodological limitations render their efficacy equivocal for postpartum depression with limited strong evidence available to guide practice or policy recommendations. CONCLUSIONS: Despite the recent upsurge of interest in this area, many questions remain unanswered, resulting in diverse research implications. In view of the lack of randomized controlled trials, psychiatrists who are experts in the treatment of postpartum mood disorders have developed consensus guidelines. These guidelines will require regular updating as better and stronger evidence emerges.
机译：背景：尽管产后抑郁症是许多来自不同文化背景的女性的主要健康问题，但这种情感状况通常仍未得到诊断和治疗。本文的目的是从生物学的角度批判性地复习文献，以确定与产后抑郁症治疗相关的科学知识的现状。方法：从1966年至2003年，检索此评价的数据库包括MEDLINE，PubMed，CINAHL，PsycINFO，EMBASE，ProQuest，Cochrane图书馆和WHO生殖健康图书馆。使用的搜索词是产后/产后抑郁症和随机对照/临床试验以各种组合。选择了1990年至2003年以英语发表的同行评审文章作为评审对象，尽管基于良好的方法学质量和/或缺乏较新的研究成果，也选择了一些较早的研究。用于评估干预措施的标准基于美国预防服务工作队和加拿大预防保健工作队开发的标准化方法。结果：检查了九项符合研究标准的研究。研究的干预措施包括抗抑郁药，雌激素治疗，严重定时睡眠剥夺和强光治疗。尽管对与分娩无关的抑郁症的某些干预措施进行了更好的研究，但方法学上的局限性使其对产后抑郁症的疗效尚无定论，可用于指导实践或政策建议的证据也很有限。结论：尽管最近对该领域的兴趣激增，但许多问题仍未得到解答，导致了各种各样的研究意义。鉴于缺乏随机对照试验，治疗产后情绪障碍专家的精神科医生已制定共识指南。随着越来越多的证据的出现，这些准则将需要定期更新。

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