...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Branched chain amino acid treatment of tardive dyskinesia in children and adolescents.
【24h】

Branched chain amino acid treatment of tardive dyskinesia in children and adolescents.

机译：支链氨基酸治疗儿童和青少年迟发性运动障碍。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: A series of studies had demonstrated that deficient clearance of the large neutral amino acid phenylalanine was associated with tardive dyskinesia (TD), that the administration of the branched chain amino acids (BCAA) significantly decreased TD symptoms over placebo, and that the observed TD symptom reduction was significantly correlated with a diminished availability of phenylalanine to the brain of adult men with psychosis. As part of an initiative by the National Institute of Mental Health to expand the testing of treatments that were successful in adults to children and adolescents, the present pilot study was undertaken to test whether the BCAA would also reduce TD symptoms in children and adolescents. A 2-week trial of the BCAA was thus conducted in 6 children and adolescents (age range, 10.5-16.5 years) for the treatment of TD symptoms. METHOD: A clinical diagnosis of TD was made in all subjects on the basis of a global score derived from the Simpson Abbreviated Dyskinesia Rating Scale. Subjects were videotaped for TD evaluation at baseline and after 1 and 2 weeks of BCAA treatment given in the form of a drink administered 3 times daily. TD symptom change over the trial period was evaluated by researchers blinded to the treatment status of the evaluation. RESULTS: TD symptom decreases were substantial in 5 of the 6 participants, ranging from 40% to 65%. Two of the subjects received an additional course of treatment, and further reductions in TD symptoms over those seen in the 2-week trial were observed. CONCLUSION: The substantial symptom decrease and tolerability observed suggest the use of the BCAA formulation for the treatment of TD in children and adolescents and warrant further large-scale studies.
机译：背景：一系列研究表明，大中性氨基酸苯丙氨酸清除率不足与迟发性运动障碍（TD）有关，支链氨基酸（BCAA）的施用明显降低了安慰剂的TD症状，并且观察到TD症状的减少与精神病成年男性大脑中苯丙氨酸的利用率降低显着相关。作为国家心理健康研究所扩大对成人成功的治疗方法的测试的一部分，儿童和青少年进行了本试验研究，以测试BCAA是否也可以减轻儿童和青少年的TD症状。因此，在6名儿童和青少年（年龄范围10.5-16.5岁）中进行了为期2周的BCAA试验，以治疗TD症状。方法：根据辛普森缩写的运动障碍评估量表得出的总体评分，对所有受试者进行TD的临床诊断。在基线时以及以每天3次的饮料形式给予BCAA治疗1和2周后，对受试者进行录像以进行TD评估。研究人员对试验期间的TD症状变化进行了评估，而研究人员对该评估的治疗状态视而不见。结果：6名参与者中有5名的TD症状明显减轻，范围从40％到65％。其中两个受试者接受了额外的疗程，并且观察到TD症状较2周试验中的症状进一步减轻。结论：观察到的症状减轻和耐受性明显改善，提示使用BCAA制剂治疗儿童和青少年的TD，值得进一步进行大规模研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号