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首页> 外文期刊>The journal of clinical psychiatry >Paroxetine Response and Tolerability Among Ethnic Minority Patients With Mood or Anxiety Disorders: A Pooled Analysis.
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Paroxetine Response and Tolerability Among Ethnic Minority Patients With Mood or Anxiety Disorders: A Pooled Analysis.

机译：帕罗西汀对患有情绪或焦虑症的少数民族患者的反应和耐受性：汇总分析。

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BACKGROUND: Because of the poor quality of mental health care received by minorities, analyses documenting comparable response to and tolerability of medications for anxiety and depression in large samples of minority and majority populations could increase the willingness of providers and patients to use medications in minority populations. METHOD: A pooled analysis of 14,875 adults who participated in 104 double-blind, placebo-controlled paroxetine clinical trials investigating major depression, panic disorder, generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, posttraumatic stress disorder, or premenstrual dysphoric disorder from March 1984 through March 2002. An intent-to-treat analysis with last observation carried forward used the Clinical Global Impressions (CGI) scale to measure dichotomous outcome, classified as either response (CGI score of 1 or 2) or more complete response (CGI score of 1) ("full response"). Minority group differences were examined using logistic regression for the entire sample and repeated for those with major depression. Adverse events greater than 5% and twice the rate of placebo were descriptively tabulated. Finally, a survival analysis examined group differences in speed of onset of response. RESULTS: Hispanic and Asian subjects had a slightly lower response rate, while Asians had the highest rates and Hispanics had the lowest rates of full response. to be due to a higher placebo response rate. There was no treatment by minority group interaction for depressed patients. Speed of response and adverse effects were similar across groups. CONCLUSIONS: There were few consistent differences in medication response and tolerability. These findings may serve to counteract the greater rate of negative attitudes toward medication use among minorities and reinforce the value of medications used to treat anxiety and depression in minorities.
机译：背景：由于少数族裔所接受的心理保健质量较差，对大量少数族裔和多数族裔样本中焦虑和抑郁药物的可比性反应和耐受性进行分析的文献分析可能会提高提供者和患者在少数族裔人群中使用药物的意愿。方法：对参与分析104项双盲，安慰剂对照的帕罗西汀临床试验的14875名成年人的汇总分析，这些临床试验涉及重度抑郁症，恐慌症，广义焦虑症，社交焦虑症，强迫症，创伤后应激障碍或经前烦躁不安从1984年3月到2002年3月进行的意向性治疗分析，最后进行的观察使用临床总体印象量表（CGI）来衡量二分结果，分为反应（CGI评分为1或2）或较完全反应（ CGI分数为1）（“完全响应”）。使用logistic回归检查整个样本的少数族裔差异，并对患有严重抑郁症的样本重复进行。描述性地列出了大于5％的不良事件和安慰剂比率的两倍。最后，一项生存分析检查了各组反应开始速度的差异。结果：西班牙裔和亚裔受试者的缓解率略低，而亚裔人群的完全缓解率最高，西班牙裔患者的完全缓解率最低。归因于较高的安慰剂反应率。抑郁症患者没有少数群体相互作用的治疗方法。各组的反应速度和不良反应相似。结论：在药物反应和耐受性方面几乎没有一致的差异。这些发现可能有助于抵消少数群体对药物使用的消极态度的增加，并增强用于治疗少数群体焦虑和抑郁症的药物的价值。

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