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首页> 外文期刊>The journal of clinical psychiatry >Behavioral Treatment of Obesity in Patients Taking Antipsychotic Medications.
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Behavioral Treatment of Obesity in Patients Taking Antipsychotic Medications.

机译：服用抗精神病药物的肥胖患者的行为治疗。

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OBJECTIVE: Antipsychotic medications are associated with weight gain and metabolic dysregulation, yet little is known about the management of obesity among individuals with severe and persistent mental illness. Thus we sought to evaluate the potential utility of a behavioral weight control program for this population. METHOD: Outpatients receiving psychiatric care at a university medical center who had a body mass index (BMI; weight in kg/[height in m](2)) >/= 30 and were currently taking antipsychotic medication participated in a 12-week group behavioral weight control program. A medical chart review was conducted for each participant's body weight over the 10 months prior to beginning the program. A multiple baseline design was used to determine the impact of the intervention on BMI through 12-month posttreatment follow-up. We also assessed self-reported eating behavior, physical activity, and health-related quality of life. Data were collected from October 2000 to July 2003. RESULTS: Among 35 patients who began the program, 29 (83%) completed treatment, with mean (+/- SD) weight loss of 5.04 (+/- 7.52) pounds (p = .001) and improvements in eating, activity, and quality of life. At 3-month posttreatment follow-up (N = 27; 77%), total mean weight loss was 7.14 (+/- 11.47) pounds (p = .003). Results of a longitudinal model based on general estimating equations indicated that, relative to the pretreatment period, BMI decreased significantly during treatment and remained stable through 12-month posttreatment follow-up. CONCLUSION: Behavioral weight control is a promising approach to the treatment of obesity among outpatients taking antipsychotic medications, but longer and more robust interventions are needed.
机译：目的：抗精神病药物与体重增加和代谢异常有关，但对于患有严重和持续性精神疾病的个体中肥胖的管理知之甚少。因此，我们试图评估该人群的行为体重控制程序的潜在效用。方法：在大学医疗中心接受精神病治疗的门诊患者的体重指数（BMI;体重（kg体重/身高，m）（2））> / = 30，并且目前正在服用抗精神病药物，参加了为期12周的研究行为体重控制程序。在开始该计划之前的10个月中，对每个参与者的体重进行了医学图表审查。在治疗后12个月的随访中，采用了多个基线设计来确定干预对BMI的影响。我们还评估了自我报告的饮食行为，体育锻炼以及与健康相关的生活质量。从2000年10月至2003年7月收集了数据。结果：在开始该计划的35位患者中，有29位（83％）完成了治疗，平均体重减轻（+/- SD）为5.04（+/- 7.52）磅（p = .001），并改善饮食，活动和生活质量。在治疗后3个月的随访中（N = 27; 77％），总平均体重减轻为7.14（+/- 11.47）磅（p = .003）。基于一般估计方程的纵向模型结果表明，相对于治疗前期间，BMI在治疗期间显着下降，并且在治疗后12个月的随访中保持稳定。结论：行为体重控制是一种在服用抗精神病药物的门诊患者中治疗肥胖的有前途的方法，但需要更长和更有效的干预措施。

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