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首页> 外文期刊>The journal of clinical psychiatry >A 4-fold risk of metabolic syndrome in patients with schizophrenia: the Northern Finland 1966 Birth Cohort study.
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A 4-fold risk of metabolic syndrome in patients with schizophrenia: the Northern Finland 1966 Birth Cohort study.

机译：精神分裂症患者发生代谢综合征的风险是其的4倍：北芬兰1966年出生队列研究。

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OBJECTIVE: Schizophrenia is associated with a shortened life expectancy and increased somatic comorbidity with, e.g., cardiovascular disorders. One major risk factor for these disorders is the metabolic syndrome, which has been reported to have a higher frequency in schizophrenic patients. Our objective was to study the prevalence of metabolic syndrome in a population-based birth cohort. METHOD: The study sample consisted of 5613 members of the Northern Finland 1966 Birth Cohort who participated in the field study from 1997 to 1998. Subjects were divided into 4 diagnostic categories (DSM-III-R): (1) schizophrenia (N = 31), (2) other functional psychoses (N = 22), (3) nonpsychotic disorders (N = 105), and (4) no psychiatric hospital treatment (N = 5455, comparison group). Subjects were assessed for the presence of metabolic syndrome according to the criteria of the National Cholesterol Education Program. RESULTS: The prevalence of metabolic syndrome was higher in subjects with schizophrenia compared with the comparison group (19% vs. 6%, p = .010). The prevalence of metabolic syndrome in subjects with other psychoses was 5%. After controlling for sex, the results of logistic regression analysis showed that the risk of metabolic syndrome in schizophrenia was 3.7 (95% CI = 1.5 to 9.0). CONCLUSIONS: The high prevalence of metabolic syndrome in schizophrenia even at such a relatively young age underscores the need to select antipsychotic medications with no or little capability to induce metabolic side effects. Also, developing comprehensive efforts directed at controlling weight and diet and improving physical activity are needed.
机译：目的：精神分裂症与预期寿命缩短和躯体合并症增加（例如心血管疾病）有关。这些疾病的主要危险因素之一是代谢综合征，据报道在精神分裂症患者中代谢综合征的发生频率更高。我们的目标是研究以人口为基础的出生队列中代谢综合征的患病率。方法：研究样本由5 613名北芬兰1966年出生的队列成员组成，他们参加了1997年至1998年的现场研究。受试者分为4个诊断类别（DSM-III-R）：（1）精神分裂症（N = 31 ），（2）其他功能性精神病（N = 22），（3）非精神病性疾病（N = 105）和（4）未接受精神科医院治疗（N = 5455，对照组）。根据国家胆固醇教育计划的标准对受试者进行了代谢综合征的评估。结果：与对照组相比，精神分裂症患者的代谢综合征患病率更高（19％比6％，p = .010）。其他精神病患者的代谢综合征患病率为5％。控制性别后，逻辑回归分析结果显示，精神分裂症的代谢综合征风险为3.7（95％CI = 1.5至9.0）。结论：即使在相对年轻的年龄，精神分裂症中代谢综合征的患病率仍很高，这表明需要选择没有或几乎没有能力诱导代谢性副作用的抗精神病药物。而且，需要针对控制体重和饮食并改善体育锻炼而做出综合努力。

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