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Differences in Axis I and II comorbidity between bipolar I and II disorders and major depressive disorder.

机译:I型和II型双相情感障碍与重度抑郁症之间的I轴和II轴合并症的差异。

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OBJECTIVE: To obtain a comprehensive view of differences in current comorbidity between bipolar I and II disorders (BD) and (unipolar) major depressive disorder (MDD), and Axis I and II comorbidity in BD in secondary-care psychiatric settings. METHOD: The psychiatric comorbidity of 90 bipolar I and 101 bipolar II patients from the Jorvi Bipolar Study and 269 MDD patients from the Vantaa Depression Study were compared. We used DSM-IV criteria assessed by semistructured interviews. Patients were inpatients and outpatients from secondary-care psychiatric units. Comparable information was collected on clinical history, index episode, symptom status, and patient characteristics. RESULTS: Bipolar disorder and MDD differed in prevalences of current comorbid disorders, MDD patients having significantly more Axis I comorbidity (69.1% vs. 57.1%), specifically anxiety disorders (56.5% vs. 44.5%) and cluster A (19.0% vs. 9.9%) and C (31.6% vs. 23.0%) personality disorders. In contrast, BD had more single cluster Bpersonality disorders (30.9% vs. 24.6%). Bipolar I and bipolar II were similar in current overall comorbidity, but the prevalence of comorbidity was strongly associated with the current illness phase. CONCLUSIONS: Major depressive disorder and BD have somewhat different patterns in the prevalences of comorbid disorders at the time of an illness episode, with differences particularly in the prevalences of anxiety and personality disorders. Current illness phase explains differences in psychiatric comorbidity of BD patients better than type of disorder.
机译:目的:全面了解二级和二级精神病患者双相性I和II型障碍(BD)和(单相性)重度抑郁症(MDD)与BD中I和II轴合并症之间当前合并症的差异。方法:比较了Jorvi双极研究的90例双极I型患者和101例双极II型患者的精神病合并症以及Vantaa抑郁症研究的269例MDD患者的精神病合并症。我们使用通过半结构化访谈评估的DSM-IV标准。患者是二级精神病科的住院患者和门诊患者。收集了有关临床病史,指数发作,症状状态和患者特征的可比信息。结果:双相情感障碍和MDD在当前合并症中的患病率有所不同,MDD患者的轴I合并症显着多(69.1%vs. 57.1%),特别是焦虑症(56.5%vs. 44.5%)和A组(19.0%vs。 9.9%)和C型人格障碍(分别为31.6%和23.0%)。相比之下,BD有更多的单簇人格障碍(30.9%对24.6%)。双相I型和双相II型在当前总体合并症中相似,但合并症的患病率与当前疾病阶段密切相关。结论:重度抑郁症和BD在疾病发作时合并症的患病率有一些不同的模式,特别是在焦虑和人格障碍的患病率方面。当前的疾病阶段比BD类型更好地解释了BD患者的精神病合并症。

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