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首页> 外文期刊>The journal of clinical psychiatry >Tobacco use before, at, and after first-episode psychosis: A systematic meta-analysis
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Tobacco use before, at, and after first-episode psychosis: A systematic meta-analysis

机译：第一次精神病之前，之后和之后的烟草使用：系统的荟萃分析

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Objective: Patients with first-episode psychosis have a high prevalence of tobacco use. We aimed to examine the prevalence and course of tobacco use during early psychosis using meta-analysis. Data Sources: Systematic search of MEDLINE (1948-2011), Embase (1947-2011), CINAHL (1984-2011), PsycINFO (1967-2011), and ISI Web of Science (1900-2011) using the search terms [psychosis OR schizophrenia] AND [tobacco OR smoking OR nicotine]. Study Selection: We located 10 studies reporting the age at initiation of daily tobacco use and the age at onset of psychosis, 31 studies reporting prevalence of tobacco use in patients with first-episode psychosis, 10 studies comparing smoking to age-/gender-matched controls, and 7 studies reporting prevalence of tobacco use at intervals after treatment. Data Extraction: The following data were extracted: age at initiation of daily tobacco use and at onset of psychosis, the proportion of patients with first-episode psychosis who used tobacco, the proportion of the general population who used tobacco, and the proportion of patients with psychosis who used tobacco at various intervals after initiation of antipsychotic treatment. Results: The pooled estimate for the interval between initiation of tobacco use and the onset of psychosis was 5.3 years (standardized mean difference = 0.85). The estimated prevalence of tobacco users in first episode of psychosis is 58.9% (95% CI, 54.3%-63.4%). There is a strong association between first-episode psychosis and tobacco use (OR = 6.04; 95% CI, 3.03-12.02) compared with healthy controls. The prevalence of tobacco use at intervals between 6 and 120 months after treatment remained unchanged (OR = 0.996; 95% CI, 0.907-1.094). Conclusions: Patients with first-episode psychosis tend to have smoked for some years prior to the onset of psychosis, have high prevalence of tobacco use at the time of presenting for treatment, and are much more likely to smoke than aged-matched controls. Their apparent difficulty in quitting has implications for tobacco cessation programs and efforts to reduce cardiovascular disease among people with mental illness.
机译：目的：首发精神病患者的吸烟率很高。我们的目的是使用荟萃分析来检查早期精神病期间烟草使用的流行程度和过程。数据来源：使用搜索词[psychosis]对MEDLINE（1948-2011），Embase（1947-2011），CINAHL（1984-2011），PsycINFO（1967-2011）和ISI Web of Science（1900-2011）进行系统搜索或精神分裂症]和[烟草或吸烟或尼古丁]。研究选择：我们找到了10项报告，报告每日吸烟开始时的年龄和精神病发作的年龄，31项报告了首发精神病患者中吸烟的患病率，10项比较吸烟与年龄/性别匹配的研究对照，还有7项研究报告了治疗后每隔一段时间吸烟的流行率。数据提取：提取以下数据：开始每天吸烟和精神病发作时的年龄，第一次吸烟的精神病患者所占的比例，使用烟草的普通人群所占的比例以及患者所占的比例患有精神病的人在开始抗精神病药物治疗后的不同时间间隔使用了烟草。结果：从开始使用烟草到精神病发作的时间间隔的汇总估计值为5.3年（标准平均差= 0.85）。第一次精神病发作中吸烟者的估计患病率为58.9％（95％CI，54.3％-63.4％）。与健康对照组相比，首发精神病与吸烟之间有很强的关联性（OR = 6.04; 95％CI，3.03-12.02）。治疗后6个月至120个月之间的烟草使用流行率保持不变（OR = 0.996; 95％CI，0.907-1.094）。结论：首发精神病患者在精神病发作之前往往已经吸烟了数年，在就诊时吸烟的流行率很高，并且与老年匹配对照组相比吸烟的可能性更高。他们明显的戒烟困难对戒烟计划和减少精神病患者心血管疾病的努力有影响。

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