...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Interferon-induced depression in chronic hepatitis C: A systematic review and meta-analysis
【24h】

Interferon-induced depression in chronic hepatitis C: A systematic review and meta-analysis

机译：干扰素诱发的慢性丙型肝炎抑郁症：系统评价和荟萃分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To carry out a systematic review of the risk factors for, and incidence of, major depressive episode (MDE) related to antiviral therapy for chronic hepatitis C. Data Sources: The MEDLINE, PsycINFO, and Cochrane databases were searched to locate articles published from the earliest available online year until June 2011 using the keywords hepatitis C, interferon-alpha, peginterferon, pegylated interferon, depression, and mood and Boolean operators. Articles written in English, Spanish, and French were included. Study Selection: Prospective studies reporting incidence of interferon-alpha-induced MDE were included. At baseline, patients did not present a DSM-IV/ICD depressive episode, and evaluation was performed by a trained clinician. Twenty-six observational studies met the inclusion criteria. Data Extraction: Extracted data included authors, year of publication, design, characteristics of the population, viral coinfection, adjunctive psychopharmacology, instruments to assess depression, dose and type of interferon-alpha, adjunctive ribavirin treatment, and follow-up time. Outcome of incidence of MDE (primary outcome measure) was abstracted, as were potential predictive variables. Data Synthesis: A full review was performed. Meta-analysis of the cumulative incidence of induced MDE as a function of time was carried out. Odds ratios (ORs) and mean differences were used to estimate the strength of association of variables. Results: Overall cumulative incidence of depression was 0.25 (95% CI, 0.16 to 0.35) and 0.28 (95% CI, 0.17 to 0.42) at 24 and 48 weeks of treatment, respectively. According to our analysis, high baseline levels of interleukin 6 (mean difference = 1.81; 95% CI, 1.09 to 2.52), female gender (OR = 1.40; 95% CI, 1.02 to 1.91), history of MDE (OR = 3.96; 95% CI, 2.52 to 6.21), history of psychiatric disorder (OR = 3.18; 95% CI, 1.60 to 6.32), subthreshold depressive symptoms (mean difference = 0.96; 95% CI, 0.31 to 1.61), and low educational level (mean difference = -0.99; 95% CI, -1.59 to -0.39) were predictive variables of MDE during antiviral treatment. Conclusions: One in 4 chronic hepatitis C patients who start interferon and ribavirin treatment will develop an induced major depressive episode. Clinicians should attempt a full evaluation of patients before starting antiviral treatment in order to identify those at risk of developing interferon-induced depression.
机译：目的：对与慢性丙型肝炎抗病毒治疗有关的严重抑郁发作（MDE）的危险因素和发生率进行系统的回顾。数据来源：检索MEDLINE，PsycINFO和Cochrane数据库以查找发表的文章从最早的在线年度开始到2011年6月，使用关键字丙型肝炎，干扰素-α，聚乙二醇干扰素，聚乙二醇化干扰素，抑郁症和情绪和布尔运算符。包括用英语，西班牙语和法语撰写的文章。研究选择：前瞻性研究报告了干扰素-α诱导的MDE发生率。基线时，患者未出现DSM-IV / ICD抑郁发作，并且由受过训练的临床医生进行评估。二十六项观察性研究符合纳入标准。数据提取：提取的数据包括作者，出版年份，设计，人群特征，病毒共感染，辅助心理药理学，评估抑郁症的手段，干扰素-α的剂量和类型，辅助利巴韦林治疗以及随访时间。 MDE（主要结局指标）发生率的结果以及潜在的预测变量也被抽象出来。数据综合：进行了全面审查。进行了MDE累积发生率随时间变化的荟萃分析。奇数比（OR）和均值差用于估计变量关联的强度。结果：在治疗的第24周和第48周，抑郁症的总累积发病率分别为0.25（95％CI，0.16至0.35）和0.28（95％CI，0.17至0.42）。根据我们的分析，白细胞介素6的基线水平高（平均差异= 1.81; 95％CI，1.09至2.52），女性（OR = 1.40; 95％CI，1.02至1.91），MDE病史（OR = 3.96; 95％CI，2.52至6.21），精神病史（OR = 3.18; 95％CI，1.60至6.32），阈下抑郁症状（平均差异= 0.96; 95％CI，0.31至1.61），文化程度低（平均差异= -0.99; 95％CI（-1.59至-0.39）是抗病毒治疗期间MDE的预测变量。结论：开始接受干扰素和利巴韦林治疗的四分之一慢性丙型肝炎患者将出现诱发的严重抑郁发作。在开始抗病毒治疗之前，临床医生应尝试对患者进行全面评估，以发现有发展为干扰素诱发抑郁症风险的患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号