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首页> 外文期刊>The journal of clinical psychiatry >A direct, controlled, blind family study of dsm-iv pathological Gambling
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A direct, controlled, blind family study of dsm-iv pathological Gambling

机译：dsm-iv病理赌博的直接，对照，盲目的家庭研究

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Objective: Pathological gambling is a major public health problem. We sought to examine the familiality of pathological gambling and determine patterns of familial aggregation of disorders. Method: We assessed probands with DSM-IV pathological gambling, controls, and their first-degree relatives. Detailed family history information was collected on relatives who were deceased or unavailable. Results: Ninety-five pathological gambling probands, 91 controls, and their 1,075 first-degree relatives over age 18 (537 relatives of pathological gambling probands, 538 relatives of controls) were evaluated between February 2005 and June 2010. Relatives were assessed blind to proband status. Best estimate diagnoses were assigned. Rates of lifetime pathological gambling (definite/ probable) was significantly greater among the first-degree relatives of probands with pathological gambling than among comparison relatives (11 % vs 1 %, OR=8.19, P<. 001). The prevalence of pathological gambling and subclinical pathological gambling combined was 16% and 3% in case and control relatives, respectively (OR = 6.57, P<.001). Pathological gambling relatives had higher rates of major depression (OR= 1.49, P< .05), bipolar disorder (OR = 3.82, P< .05), any mood disorder (OR = 1.59, P< .05), social anxiety disorder (OR=4.76,P<.01), any substance use disorder (OR= 1.47, P< .05), posttraumatic stress disorder (OR=2.59,P<.05), and antisocial personality disorder (OR=3.72, P< .001). Antisocial personality disorder (OR = 3.12, P<.01), social anxiety disorder (OR=4.15, P<.01), and posttraumatic stress disorder (OR = 2.85, P<.05) were more frequent in case relatives independent of the presence of pathological gambling. Age at onset of pathological gambling in case probands (<40years/>40 years) was not related to familiality in their first-degree relatives (OR= 1.03, P=.927). Conclusions: Pathological gambling is familial. Mood and substance use disorders may emerge as a consequence of the pathological gambling or as a more complex syndrome. In contrast, antisocial personality disorder, social anxiety disorder, and posttraumatic stress disorder may share a common familial etiology with pathological gambling.The phenotype may extend beyond pathological gambling to include subclinical forms of the disorder.
机译：目的：病理赌博是主要的公共卫生问题。我们试图检查病理性赌博的家族性，并确定家族性疾病聚集的模式。方法：我们通过DSM-IV病理赌博，对照及其一级亲属对先证者进行了评估。收集了详细的家族史信息，其中包括已故或无法获得的亲属。结果：2005年2月至2010年6月，评估了95名病理赌博先证者，91名对照者及其18岁以上的1,075名一级亲属（537名病理赌博先证者的亲戚，538名对照者的亲戚）。对亲戚的评估不包括先证者状态。分配了最佳估计诊断。患有病理性赌博的先证者的一级亲属中，终生病理性赌博的比率（确定/可能）显着高于比较亲戚（11％比1％，OR = 8.19，P <。001）。病例和对照亲属的病理赌博和亚临床病理赌博的患病率分别为16％和3％（OR = 6.57，P <.001）。病理性赌博亲属的严重抑郁症（OR = 1.49，P <.05），双相情感障碍（OR = 3.82，P <.05），任何情绪障碍（OR = 1.59，P <.05），社交焦虑症的发生率更高（OR = 4.76，P <.01），任何物质使用障碍（OR = 1.47，P <.05），创伤后应激障碍（OR = 2.59，P <.05）和反社会人格障碍（OR = 3.72，P <.001）。如果亲属独立于以下情况，则反社会人格障碍（OR = 3.12，P <.01），社交焦虑症（OR = 4.15，P <.01）和创伤后应激障碍（OR = 2.85，P <.05）更为频繁。存在病理性赌博。先证者（<40岁/> 40岁）发病时的病理赌博年龄与一级亲属的家族地位无关（OR = 1.03，P = .927）。结论：病理性赌博是家族性的。病态赌博或更复杂的综合症可能会导致情绪和物质使用障碍。相比之下，反社会人格障碍，社交焦虑症和创伤后应激障碍可能与病理性赌博具有相同的家族病因。

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