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SNAP25 Is Associated With Schizophrenia and Major Depressive Disorder in the Han Chinese Population

机译：SNAP25与汉族人群的精神分裂症和严重抑郁症有关

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Objective: Synaptosomal-associated protein of 25 kDa (SNAP25) is a member of the soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) protein complex, which plays essential roles in the modulation of different voltage-gated calcium channels and neurotransmitter release. Many previous studies have reported the SNAP25 gene to be significantly associated with attention-deficit/hyperactivity disorder (ADHD). Recently, shared genetic variants have been demonstrated in 5 major psychiatric disorders, including schizophrenia, major depressive disorder, bipolar disorder, autism spectrum disorders, and ADHD. However, no compelling, convincing evidence has suggested an association between SNAP25 and schizophrenia or major depressive disorder. Thus, we investigated the association between SNAP25 and both schizophrenia and major depressive disorder in the Han Chinese population.
机译：目的：25 kDa的突触体相关蛋白（SNAP25）是可溶性N-乙基马来酰亚胺敏感性因子附着受体（SNARE）蛋白复合物的成员，在调节不同的电压门控钙通道和神经递质释放中起重要作用。先前的许多研究报告称SNAP25基因与注意力缺陷/多动症（ADHD）显着相关。最近，已在5种主要精神疾病中证实了共有的遗传变异，包括精神分裂症，主要抑郁症，双相情感障碍，自闭症谱系障碍和ADHD。但是，尚无令人信服的令人信服的证据表明SNAP25与精神分裂症或重度抑郁症之间存在关联。因此，我们调查了汉族人群中SNAP25与精神分裂症和主要抑郁症之间的关系。

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