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首页> 外文期刊>The journal of clinical psychiatry >Antipsychotic drug side effect issues in bipolar manic patients.
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Antipsychotic drug side effect issues in bipolar manic patients.

机译：双相躁狂患者中的抗精神病药物副作用问题。

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While the efficacy of antipsychotics as a maintenance treatment for bipolar patients has not been systematically studied, these drugs are commonly used in the long-term treatment of bipolar patients, and it is not unusual for a bipolar patient to be taking 3 to 4 medications, including antipsychotics. Conventional antipsychotics may be comparable to lithium for acute mania, but have limitations when used in the long-term treatment of bipolar disorder. Their adverse effects, which include extrapyramidal side effects, tardive dyskinesia, weight gain, sedation, and sexual dysfunction, often lead to non-compliance; their use may have a negative impact on the overall course of illness; and they may not be as effective as lithium in treating the core manic symptoms over the long term. Atypical antipsychotics may prove useful for bipolar patients who require antipsychotic treatment because of their favorable side effect profile, thymoleptic properties, and positive effect on overall functioning.
机译：虽然尚未系统研究抗精神病药作为双相型患者维持治疗的功效，但这些药物常用于双相型患者的长期治疗，并且双相型患者服用3至4种药物并不罕见，包括抗精神病药。常规抗精神病药在急性躁狂症中可与锂媲美，但在长期用于躁郁症的治疗中具有局限性。它们的不良反应包括锥体外系副作用，迟发性运动障碍，体重增加，镇静和性功能障碍，常常导致不依从。它们的使用可能对整个疾病过程产生负面影响;从长期来看，它们可能不如锂有效。非典型抗精神病药因其有利的副作用，胸腺痛药的特性以及对整体功能的积极作用，可能对需要抗精神病药治疗的双相情感障碍患者有用。

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