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首页> 外文期刊>The journal of clinical psychiatry >The research-to-practice gap in mood disorders: a role for the U.S. Department of Veterans Affairs.
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The research-to-practice gap in mood disorders: a role for the U.S. Department of Veterans Affairs.

机译：情绪障碍的研究与实践之间的差距：美国退伍军人事务部的作用。

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There is a persistent gap between the publication of research results and the translation of these findings to routine practice. It typically takes years to decades for a treatment proven efficacious in a randomized controlled trial to be adopted in routine care. Further, for some treatments the risk-benefit profile may change substantially once disseminated. This research-to-practice gap exists in part because most treatment studies are conducted in tightly controlled settings rather than real-world patient populations. Because these treatments are initially tested in selective settings with relatively healthy patients, such evaluations often do not consider efficacy or adverse effects in more vulnerable or complex populations cared for in real-world clinical care settings. The Institute of Medicine has called this the "efficacy-effectiveness gap," a phenomenon that characterizes dissemination of all medical interventions, including interventions for mental illness.
机译：在发表研究结果与将这些发现转化为常规做法之间存在持续的差距。在随机对照试验中证明有效的治疗方法通常需要数年甚至数十年的时间才能用于常规治疗。此外，对于某些治疗，一旦传播，风险收益概况可能会发生实质性变化。之所以存在这种研究与实践之间的差距，部分原因是大多数治疗研究都是在严格控制的环境中进行的，而不是在现实世界中的患者人群中进行的。因为这些治疗最初是在相对健康的患者的选择性环境中进行测试的，所以此类评估通常不考虑在现实世界中临床护理环境中更脆弱或复杂的人群中的疗效或不良反应。医学研究所称此为“功效-效果差距”，这种现象是所有医学干预措施（包括精神疾病干预措施）传播的特征。

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