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首页> 外文期刊>The journal of clinical psychiatry >Longitudinal effects of personality disorders on psychosocial functioning of patients with major depressive disorder.
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Longitudinal effects of personality disorders on psychosocial functioning of patients with major depressive disorder.

机译：人格障碍对重度抑郁症患者心理社会功能的纵向影响。

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OBJECTIVE: No previous research has focused on psychosocial functioning in understanding how personality disorders compound the impairment caused by major depressive disorder over time. This report describes the effects of persistent and remitting comorbid personality disorders on the depressive status and functioning of patients with major depressive disorder over the course of 2 years. METHOD: Longitudinal data on functioning from the first 2 years of the Collaborative Longitudinal Personality Disorders Study were evaluated for 3 groups of subjects with major depressive disorder: subjects with major depressive disorder alone (N = 103), those with persistent comorbid personality disorders (N = 164), and those with comorbid personality disorders that remitted (N = 69). DSM-IV criteria were used for mood and personality disorder diagnoses. The data were gathered from September 1996 to August 2000 and from September 2001 to September 2004. RESULTS: Subjects whose personality disorders remitted were more likely than those with persisting personality disorders to have major depressive disorder remit. Social functioning, as measured by the Longitudinal Interval Follow-up Evaluation and the Global Assessment of Functioning, improved across a range of domains over time, with most gains occurring in the first 6 months of follow-up and with differential improvement by group. As hypothesized, subjects whose personality disorders remitted fared nearly as well as did subjects without personality disorders, whereas subjects whose personality disorders persisted functioned most poorly. CONCLUSIONS: Outcome research on major depressive disorder has often ignored Axis II disorders. Our data indicate that the longitudinal course of personality psychopathology meaningfully influences depressive outcome and psychosocial functioning in patients with major depressive disorder. The findings indicate the need to target both symptom relief and psychosocial functioning and to treat both personality and mood disorders in comorbid patients.
机译：目的：以前没有研究集中在社会心理功能上，以了解人格障碍如何随着时间的推移而加剧由重度抑郁症引起的障碍。该报告描述了持续性和缓解性合并症在两年内对抑郁症患者的抑郁状态和功能的影响。方法：对纵向性人格障碍协作研究的前两年的功能性纵向数据进行了评估，评估了3组重度抑郁症患者：仅患有重度抑郁症的患者（N = 103），患有持续性合并症的人格障碍（N = 164），以及合并的合并性人格障碍者（N = 69）。 DSM-IV标准用于情绪和人格障碍的诊断。数据收集于1996年9月至2000年8月以及2001年9月至2004年9月。结果：人格障碍缓解的受试者比持续性人格障碍的受试者更容易出现重性抑郁症。通过纵向间隔随访评估和整体功能评估来衡量，社交功能随着时间的推移在各个领域得到改善，大部分收获发生在随访的前6个月，并且按组别有所改善。如假设的那样，人格障碍缓解的受试者的表现几乎与没有人格障碍的受试者的表现一样，而人格障碍持续的受试者的功能最差。结论：关于重度抑郁症的结果研究通常忽略了Axis II疾病。我们的数据表明，人格心理病理学的纵向过程对重度抑郁症患者的抑郁结局和心理社会功能产生了有意义的影响。研究结果表明，需要同时针对症状缓解和心理社会功能，以及治疗合并症患者的人格和情绪障碍。

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