...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa.
【24h】

Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa.

机译：雄激素缺乏症：与神经性厌食症的焦虑症和抑郁症状严重程度增加相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Anorexia nervosa is associated with a high prevalence of psychiatric comorbidities, including anxiety and depression, and with endocrine dysfunction, including relative androgen deficiency compared with healthy young women. Because androgens are known to affect mood and behavior, we hypothesized that low endogenous androgen production in anorexia nervosa would predict anxiety and depression severity. METHOD: Serum androgen levels and severity of depression (Hamilton Rating Scale for Depression) and anxiety (Hamilton Rating Scale for Anxiety) were measured in 43 community-dwelling women with DSM-IV-defined anorexia nervosa from May 2004 to July 2006. RESULTS: Strong inverse associations were observed between both total and free testosterone and anxiety and depression severity, independent of weight. Free testosterone was also inversely associated with 4 eating-disordered thinking and behavior subscales of the Eating Disorder Inventory 2 (EDI-2). Mean free testosterone blood levels were lower in women with clinically significant anxiety and in women with clinically significant depression, compared with those without. In stepwise regression models, free testosterone was an important predictor of anxiety and depression severity. EDI-2 ineffectiveness, perfectionism, interpersonal distress, and social insecurity scores were also inversely associated with androgen levels, independent of weight. CONCLUSIONS: Our data suggest that low androgen levels may contribute to anxiety, depression, and eating-disordered thinking and behavior in women with anorexia nervosa and form the basis for future studies to investigate the effectiveness of androgen replacement therapy. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov identifier NCT00089843.
机译：目的：与健康的年轻女性相比，神经性厌食症与精神疾病合并症（包括焦虑症和抑郁症）的患病率高以及内分泌功能障碍（包括相对雄激素缺乏症）有关。因为已知雄激素会影响情绪和行为，所以我们假设神经性厌食症的内源性雄激素生成量低会预测焦虑和抑郁的严重程度。方法：从2004年5月至2006年7月，对43例DSM-IV定义的神经性厌食症社区居民妇女的血清雄激素水平和抑郁严重程度（汉密尔顿抑郁量表）和焦虑症（汉密尔顿焦虑量表）进行了测量。结果：在总睾丸激素和游离睾丸激素与焦虑和抑郁严重程度之间均观察到强烈的负相关，而与体重无关。游离睾丸激素还与饮食失调量表2（EDI-2）的4种饮食失调的思维和行为分量表成反比。与没有焦虑症的妇女相比，具有临床意义的焦虑症的妇女和具有临床意义的抑郁症的妇女的平均游离睾丸激素水平较低。在逐步回归模型中，游离睾丸激素是焦虑和抑郁严重程度的重要预测指标。 EDI-2无效，完美主义，人际关系困扰和社会不安全感评分也与雄激素水平呈负相关，而与体重无关。结论：我们的数据表明，低水平的雄激素可能会导致神经性厌食症妇女的焦虑，抑郁和饮食失调的思维和行为，并为进一步研究雄激素替代疗法的有效性奠定了基础。临床试验注册：ClinicalTrials.gov标识符NCT00089843。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号