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首页> 外文期刊>The journal of clinical psychiatry >The efficacy of acute electroconvulsive therapy in atypical depression.
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The efficacy of acute electroconvulsive therapy in atypical depression.

机译：急性电惊厥治疗非典型性抑郁症的疗效。

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OBJECTIVE: This study examined the characteristics and outcomes of patients with major depressive disorder (MDD), with or without atypical features, who were treated with acute bilateral electroconvulsive therapy (ECT). METHOD: Analyses were conducted with 489 patients who met DSM-IV criteria for MDD. Subjects were identified as typical or atypical on the basis of the Structured Clinical Interview for DSM-IV obtained at baseline prior to ECT. Depression symptom severity was measured by the 24-item Hamilton Rating Scale for Depression (HAM-D(24)) and the 30-item Inventory of Depressive Symptomatology-Self-Report (IDS-SR(30)). Remission was defined as at least a 60% decrease from baseline in HAM-D(24) score and a total score of 10 or below on the last 2 consecutive HAM-D(24) ratings. The randomized controlled trial was performed from 1997 to 2004. RESULTS: The typical (N = 453) and atypical (N = 36) groups differed in several sociodemographic and clinical variables including gender (p = .0071), age (p = .0005), treatment resistance (p = .0014), and age at first illness onset (p < .0001) and onset of current episode (p = .0008). Following an acute course of bilateral ECT, a considerable portion of both the typical (67.1%) and the atypical (80.6%) groups reached remission. The atypical group was 2.6 (95% CI = 1.1 to 6.2) times more likely to remit than the typical group after adjustment for age, psychosis, gender, clinical site, and depression severity based on the HAM-D(24). CONCLUSION: Acute ECT is an efficacious treatment for depressed patients with typical or atypical symptom features. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00000375.
机译：目的：本研究检查了接受急性双侧电惊厥治疗（ECT）的伴有或不伴有非典型特征的重度抑郁症（MDD）患者的特征和结局。方法：对符合DSM-IV MDD标准的489例患者进行了分析。根据在ECT之前基线获得的DSM-IV的结构化临床访谈，将受试者鉴定为典型或非典型受试者。抑郁症状的严重程度是通过24项汉密尔顿抑郁量表（HAM-D（24））和30项抑郁症状-自我报告清单（IDS-SR（30））进行测量的。缓解定义为：HAM-D（24）评分比基线降低至少60％，并且最近2个连续HAM-D（24）评分的总评分为10或以下。结果从1997年至2004年进行了随机对照试验。结果：典型（N = 453）和非典型（N = 36）组在一些社会人口统计学和临床​​变量上有所不同，包括性别（p = .0071），年龄（p = .0005）。 ），治疗抵抗力（p = .0014）以及首次发病的年龄（p <.0001）和当前发作的年龄（p = .0008）。双边ECT急性发作后，典型组（67.1％）和非典型组（80.6％）的相当一部分均达到缓解。根据HAM-D调整年龄，精神病，性别，临床部位和抑郁严重程度后，非典型组的缓解可能性比典型组高2.6倍（95％CI = 1.1至6.2）（24）。结论：急性ECT是对典型或非典型症状特征的抑郁症患者的有效治疗。试验注册：clinicaltrials.gov标识符：NCT00000375。

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