Do glutamatergic agents represent a new class of antidepressant drugs? Part 2.

Sanacora G

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Do glutamatergic agents represent a new class of antidepressant drugs? Part 2.

机译：谷氨酸能药物代表一类新的抗抑郁药吗？第2部分。

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As reviewed in part 1, mounting evidence suggests that changes in glutamate neurotransmission are associated with both the patho-physiology and treatment of major depressive disorder (MDD). The complexity of the glutamatergic neurotransmitter system provides many potential pharmacologic targets that could be exploited in the development of novel antidepressant and mood-stabilizing medications. The preceding section provided a brief overview of drugs targeting glutamate release and uptake as well as the metabotropic glutamate receptors. This section will focus on recent work on the ionotropic N-methyl-D-aspartate (NMDA) and a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors.

机译：如第1部分所述，越来越多的证据表明，谷氨酸神经传递的变化与重度抑郁症（MDD）的病理生理和治疗均相关。谷氨酸能神经递质系统的复杂性提供了许多潜在的药理学靶标，可用于开发新型抗抑郁药和稳定情绪的药物。上一节简要介绍了针对谷氨酸盐释放和摄取以及代谢型谷氨酸受体的药物。本节将重点关注离子型N-甲基-D-天冬氨酸（NMDA）和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体的最新研究。

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《The journal of clinical psychiatry》 |2009年第11期|共2页
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Sanacora G;
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正文语种 eng
中图分类精神病学;
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1. Do glutamatergic agents represent a new class of antidepressant drugs? Part 2. [J] . Sanacora G The journal of clinical psychiatry . 2009,第11期

机译：谷氨酸能药物代表一类新的抗抑郁药吗？第2部分。
2. Rapastinel, a novel glutamatergic agent with ketamine-like antidepressant actions: Convergent mechanisms [J] . Pharmacology, Biochemistry and Behavior . 2020,第期

机译：Rapastinel，一种新型谷氨酸剂，具有氯胺酮样的抗抑郁作用：收敛机制
3. The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf/ heterozygous null mice. [J] . Lindholm JS, Autio H, Vesa L, Neuropharmacology . 2012,第1期

机译：谷氨酸能药物氯胺酮和AMPA受体增强剂LY 451646的抗抑郁样作用在bdnf /杂合无效小鼠中得以保留。
4. How In-Silico Experiments can help Drug-discovery: the glutamatergic synapse as an example of application [C] . Pierre Chauvet, Jean-marc Dupont International Conference on Developments in eSystems Engineering . 2009

机译：Silico实验中如何帮助毒品发现：谷氨酰胺突触作为应用的例子
5. Part I. Asymmetric synthesis of bicyclic analogues of risedronate as molecular probes of the mechanism of action of bisphosphonate antiosteoporotic drugs and potentially more efficacious antiosteoporotic agents. Part II. Facile preparation and functionalization of chiral stabilized ylides from common chiral auxiliaries using the Bestmann ylide and their use in Wittig reactions. Part III. Asymmetric organocatalysis: 1. An investigation of alpha-hydroxylation of aldehydes; 2. Synthesis of a novel camphor-based alpha-aminotetrazole organocatalyst. [D] . Song, Xinyi. 2007

机译：第一部分：利塞膦酸盐双环类似物的不对称合成，作为双膦酸盐类抗骨质疏松药和潜在更有效的抗骨质疏松药作用机理的分子探针。第二部分使用Bestmann内酯从常见手性助剂轻松制备和官能化手性稳定化的叶基及其在Wittig反应中的用途。第三部分不对称有机催化：1.醛的α-羟基化研究； 2.合成新的基于樟脑的α-氨基四唑有机催化剂。
6. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity [O] . Mark J Field, Ryszard J Oles, Lakhbir Singh 2001

机译：普瑞巴林可能代表一类具有广泛活性的抗焦虑药
7. 2. Cannabidiol enhancement of serotonergic and glutamatergic signalling in a mouse model of depression induces fast and maintained antidepressant actions: implication of 5-HT1A receptors [O] . Linge Méndez, Raquel, Jiménez Sánchez, Laura, Campa, Leticia, 2016

机译：2.卡纳比多二醇增强抑郁症小鼠模型中的血清素能和谷氨酸能信号传导诱导快速且维持抗抑郁作用：5-HT1A受体的含义

Do glutamatergic agents represent a new class of antidepressant drugs? Part 2.

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