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首页> 外文期刊>The journal of clinical psychiatry >Family history of depression and therapeutic outcome: findings from STAR*D.
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Family history of depression and therapeutic outcome: findings from STAR*D.

机译：抑郁症家族史和治疗结局：STAR * D的发现。

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OBJECTIVE: It is unclear whether a positive family history of depression affects the clinical presentation or effectiveness of treatment for major depressive disorder (MDD). We aimed to determine whether depressed patients with a positive family history of depression differed from those without in terms of baseline sociodemographic and clinical characteristics, including concurrent comorbid conditions and treatment outcome with citalopram in a large, multicenter effectiveness trial. METHOD: Clinical outcome and sociodemographic information were collected on 2876 participants with DSM-IV MDD enrolled from July 2001 through April 2004 in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Participants with and without a family history of depression, as determined by self-report at initial assessment, were compared. RESULTS: Over half (55.6%) (1585/2853) of the evaluable sample reported a positive family history of depression. A positive family history of depression was associated with an earlier age at onset of MDD, a longer length of illness, and more comorbid generalized anxiety disorder and prior suicide attempts. These participants had a slightly faster onset of remission, and slightly greater side effect burden, but they did not differ overall in response or remission rates. CONCLUSIONS: A family history of depression was associated with several clinical characteristics, although its usefulness as a predictor of treatment outcome is questionable. The slightly faster remission with an SSRI despite the slightly greater side effect burden indicates the effectiveness of using an SSRI in treating depressed patients both with and without a family history of depression. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00021528.
机译：目的：尚不清楚抑郁症的阳性家族史是否会影响重度抑郁症（MDD）的临床表现或治疗效果。我们的目的是在一项大型的多中心有效性试验中，确定具有阳性抑郁家族史的抑郁患者是否与没有基线社会人口统计学和临床​​特征的患者（包括并发合并症和西酞普兰的治疗结果）不同。方法：从2001年7月至2004年4月，在2876名DSM-IV MDD参与者中收集了临床结局和社会人口统计学信息，这些参与者参加了缓解抑郁的序贯治疗替代方案（STAR * D）研究。比较了有和没有抑郁家族史的参与者，这是由初次评估时通过自我报告确定的。结果：超过一半（55.6％）（1585/2853）的可评估样本报告了抑郁症的阳性家族史。抑郁症的积极家族史与MDD发病年龄早，病程长，合并焦虑症和以前自杀未遂的合并症有关。这些参与者的缓解发作速度稍快，副作用负担也稍大，但总体反应或缓解率没有差异。结论：抑郁症的家族病史与几种临床特征有关，尽管其作为治疗结果的预测指标的有效性值得怀疑。尽管副作用稍大，但SSRI的缓解速度稍快，这表明使用SSRI可以有效治疗患有抑郁症和无家族史的抑郁症患者。试验注册：clinicaltrials.gov标识符：NCT00021528。

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