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Substance-induced psychosis: a diagnostic conundrum.

机译:物质诱发的精神病:诊断难题。

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OBJECTIVE: To critically examine the DSM-IV-TR criteria for substance-induced psychotic disorder (SIPD). DATA SOURCES: Leading electronic databases (such as MEDLINE, PubMed) were searched for the years 1992 through 2007, using combinations of the following key search terms: substance abuse/dependence, alcohol, marijuana, cannabis, methamphetamine, crack, cocaine, amphetamine, ecstasy, ketamine, phencyclidine, LSD, mental health, drug-induced psychosis, substance-induced psychosis, psychosis, and schizophrenia. References identified from bibliographies of pertinent articles and books in the field were also collected and reviewed. DATA EXTRACTION: Only research studies or case reports/series that presented data on populations diagnosed with SIPD by using clinical or structured diagnostic interviews and that were published in English were used to assess the validity of the current SIPD criteria. DATA SYNTHESIS: We identified 49 articles that presented clinical data on SIPD. Almost half of these publications were case reports, with 18 articles specifically focusing on delineating the clinical characteristics or outcomes of individuals diagnosed with SIPD. While several large studies have recently been conducted to assess the stability of SIPD, there is a dearth of research that rigorously examines the validity of DSM-IV diagnostic criteria across substances. CONCLUSIONS: There remains a striking paucity of information on the outcome, treatment, and best practice for substance-associated psychotic episodes. Further work is clearly required before the advent of DSM-V. We propose an alternative, broader classification that better reflects the current evidence base, inferring association rather than causation.
机译:目的:严格审查DSM-IV-TR标准的物质性精神病(SIPD)。数据来源:从1992年到2007年,使用以下关键搜索词的组合对领先的电子数据库(例如MEDLINE,PubMed)进行了搜索:药物滥用/依赖性,酒精,大麻,大麻,甲基苯丙胺,裂缝,可卡因,苯丙胺,摇头丸,氯胺酮,苯环利定,LSD,精神健康,药物引起的精神病,物质引起的精神病,精神病和精神分裂症。从该领域相关文章和书籍的书目中发现的参考文献也被收集和审查。数据提取:仅使用通过临床或结构化诊断访谈提供以SIPD诊断的人群数据并以英文发表的研究或病例报告/系列,以评估当前SIPD标准的有效性。数据综合:我们确定了49篇文章,介绍了SIPD的临床数据。这些出版物中几乎有一半是病例报告,有18篇文章专门研究了被诊断为SIPD的个体的临床特征或结果。尽管最近进行了几项大型研究以评估SIPD的稳定性,但缺乏严格研究跨物质的DSM-IV诊断标准有效性的研究。结论:关于与物质有关的精神病发作的结果,治疗和最佳实践的信息仍然很少。在DSM-V出现之前,显然需要进一步的工作。我们提出了另一种更广泛的分类,可以更好地反映当前的证据基础,从而推断关联而不是因果关系。

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