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首页> 外文期刊>The journal of clinical psychiatry >Cortical Stimulation of the Prefrontal Cortex With Transcranial Direct Current Stimulation Reduces Cue-Provoked Smoking Craving: A Randomized, Sham-Controlled Study.
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Cortical Stimulation of the Prefrontal Cortex With Transcranial Direct Current Stimulation Reduces Cue-Provoked Smoking Craving: A Randomized, Sham-Controlled Study.

机译：经颅直流电刺激前额叶皮层的皮质刺激减少了提示诱发的吸烟渴望：一项随机，假对照研究。

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OBJECTIVE: Because neuroimaging studies have shown that cue-provoked smoking craving is associated with changes in the activity of the bilateral dorsolateral prefrontal cortex (DLPFC), we aimed to investigate whether a powerful technique of noninvasive brain stimulation, transcranial direct current stimulation (tDCS), reduces cue-provoked smoking craving as indexed by a visual analog scale. METHOD: We performed a randomized, sham-controlled crossover study in which 24 subjects received sham and active tDCS (anodal tDCS of the left and right DLPFC) in a randomized order. Craving was induced by cigarette manipulation and exposure to a smoking video. The study ran from January 2006 to October 2006. RESULTS: Smoking craving was significantly increased after exposure to smoking-craving cues (p < .0001). Stimulation of both left and right DLPFC with active, but not sham, tDCS reduced craving significantly when comparing craving at baseline and after stimulation, without (p = .007) and with (p = .005) smoking-craving cues. There were no significant mood changes in any of the conditions of stimulation. Adverse events were mild and distributed equally across all treatment conditions. CONCLUSIONS: Our findings extend the results of a previous study on the use of brain stimulation to reduce craving, showing that cortical stimulation with tDCS is beneficial for reducing cue-provoked craving, and thus support the further exploration of this technique for smoking cessation.
机译：目的：由于神经影像学研究表明，提示诱发吸烟的渴望与双侧背外侧前额叶皮层（DLPFC）的活动变化有关，因此我们旨在研究无创脑刺激，经颅直流电刺激（tDCS）的有效技术减少视觉提示量表指示的提示诱发吸烟的渴望。方法：我们进行了一项随机的，以假手术为对照的交叉研究，其中24名受试者随机接受假手术和主动tDCS（左右DLPFC的阳极tDCS）。渴望是由香烟操纵和暴露于吸烟视频引起的。该研究于2006年1月至2006年10月进行。结果：暴露于渴望吸烟的线索后，吸烟渴望显着增加（p <.0001）。当比较基线和刺激后的渴望时，不使用（p = .007）和使用（p = .005）吸烟渴望提示时，tDCS可以通过主动而非假刺激的左右DLPFC刺激显着降低渴望。在任何刺激条件下都没有明显的情绪变化。不良事件轻微，在所有治疗条件下均等分布。结论：我们的发现扩展了先前关于使用脑刺激减少渴望的研究的结果，表明用tDCS刺激皮质对减少提示诱发的渴望是有益的，因此支持该技术对戒烟的进一步探索。

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