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首页> 外文期刊>The journal of clinical psychiatry >Body mass index and response to antidepressants in depressed research subjects.
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Body mass index and response to antidepressants in depressed research subjects.

机译：抑郁症研究对象的体重指数和对抗抑郁药的反应。

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To the Editor: Recent investigations indicate that obese individuals are more prone to depression than nonobese individuals and depressed patients are more overweight than nondepressed people. This might be because chronic physical (eg, obesity) and psychological (eg, depression) stress sets off systemic inflammatory reactions in the body. Such low-grade, generalized inflammation could contribute to, among other things, chronic or aging diseases, including coronary artery disease, diabetes, cancer, and Alzheimer's disease. Independent of aging, inflammatory markers (such as C-reactive protein) have been linked with mood disorders, especially major depressive disorder (MDD). Lydiard5 has suggested that antidepressant effects of antidepres-sants are mainly due to their stress-buffering properties. Finally, Rosmond proposes the idea that obesity and depression might represent different manifestations of the same disease process; dysregulation of certain common pathways or neurotransmit-ters can increase an individual's vulnerability to both depression and obesity.
机译：致编辑：最近的调查表明，肥胖者比非肥胖者更容易抑郁，而抑郁症患者比非抑郁症患者更重。这可能是因为长期的身体压力（例如肥胖）和心理压力（例如抑郁）在体内引起全身性炎症反应。这种低度的普遍性炎症可能会导致慢性或衰老性疾病，其中包括冠状动脉疾病，糖尿病，癌症和阿尔茨海默氏病。独立于衰老，炎症标志物（例如C反应蛋白）已与情绪障碍，尤其是重度抑郁症（MDD）相关。 Lydiard5认为抗抑郁药的抗抑郁作用主要是由于其应力缓冲特性。最后，罗斯蒙德提出了肥胖和抑郁可能代表同一疾病过程的不同表现的想法。某些常见途径或神经递质的失调会增加个体对抑郁和肥胖的脆弱性。

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