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首页> 外文期刊>The journal of clinical psychiatry >Can we incorporate psychosocial treatment interventions into psychopharmacology clinical trials?
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Can we incorporate psychosocial treatment interventions into psychopharmacology clinical trials?

机译：我们可以将心理社会治疗干预措施纳入心理药理学临床试验中吗？

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The article by Richard Keefe and colleagues1 in this month's Journal has substantial value to researchers who face an important methodological question in clinical trials of cognitive-enhancing medications in schizophrenia. Do patients in pharmacologic intervention trials need to exercise their cognitive "muscles" for a drug that increases cognitive "muscle mass" to work? This is the analogy offered by these authors. Exercise is defined as some form of training in cognitive skills, such as cognitive remediation. Often, discussion of this question is side-tracked by a procedural question, namely, can introducing a cognitive remediation intervention into large, multicenter randomized clinical trials (RCTs) of medication be feasible? First, there is the concern that staff at the clinical sites where trials are conducted will not be able to implement the procedures, and, second, there is concern that patients who enroll in these trials will not actually participate adequately in cognitive remediation activities involving multiple training sessions per week over several months.
机译：理查德·基夫（Richard Keefe）和同事在本月刊上发表的文章1对于在精神分裂症认知增强药物的临床试验中面临重要方法论问题的研究人员具有重大价值。进行药理干预试验的患者是否需要锻炼自己的认知“肌肉”才能使药物增加认知“肌肉量”才能起作用？这是这些作者提供的类比。运动被定义为某种形式的认知技能训练，例如认知补救。通常，这个问题的讨论会被程序问题所困扰，也就是说，将认知补救干预措施引入大型，多中心的药物随机临床试验（RCT）是否可行？首先，令人担忧的是，进行临床试验的临床工作人员将无法执行该程序;其次，令人担忧的是，参加这些试验的患者实际上不会充分参与涉及多个领域的认知修复活动几个月的每周培训课程。

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