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首页> 外文期刊>The journal of clinical psychiatry >Right versus left prefrontal transcranial magnetic stimulation for obsessive-compulsive disorder: a preliminary investigation.
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Right versus left prefrontal transcranial magnetic stimulation for obsessive-compulsive disorder: a preliminary investigation.

机译：右与左前额经颅磁刺激治疗强迫症的初步研究。

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BACKGROUND: There is preliminary evidence that repetitive transcranial magnetic stimulation (rTMS) may be useful for the treatment of obsessive-compulsive disorder (OCD), but no definitive study has been published, and the effect of laterality of stimulation is uncertain. METHOD: Subjects (N = 12) with resistant OCD were allocated randomly to either right or left prefrontal rTMS daily for 2 weeks and were assessed by an independent rater at 1 and 2 weeks and 1 month later. RESULTS: Subjects had an overall significant improvement in the obsessions (p < .01), compulsions (p < .01), and total (p < .01) scores on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) after 2 weeks and at 1-month follow-up. This improvement was significant for obsessions (p < .05) and tended to significance for total Y-BOCS scores (p = .06) after correction for changes in depression scores on the Montgomery-Asberg Depression Rating Scale. There was no significant difference between right- and left-sided rTMS on any of the parameters examined. Two subjects (33%) in each group showed a clinically significant improvement that persisted at I month but with relapse later in I subject. CONCLUSION: A proportion (about one quarter) of patients with resistant OCD appear to respond to rTMS to either prefrontal lobe, although in the absence of a sham treatment group in this study, we cannot rule out the possibility of this being a placebo response. This treatment warrants further investigation to better establish its efficacy and examine the best parameters for response.
机译：背景：有初步证据表明，重复经颅磁刺激（rTMS）可用于治疗强迫症（OCD），但尚未发表明确的研究，并且刺激的侧向作用尚不确定。方法：将耐OCD的受试者（N = 12）随机分配到右前额叶rTMS或左前额叶rTMS，连续2周，并在1、2周和1个月后由独立评估者进行评估。结果：受试者在2分后的耶鲁-布朗强迫症量表（Y-BOCS）的痴迷度（p <.01），强迫症（p <.01）和总分（p <.01）上都有整体显着改善。周和1个月的随访。在蒙哥马利-阿斯伯格抑郁量表上对抑郁评分的变化进行校正后，这种改善对痴迷程度显着（p <.05），并且对Y-BOCS总评分也具有显着意义（p = .06）。右侧rTMS和左侧rTMS在所检查的任何参数上都没有显着差异。每组中有2名受试者（33％）表现出临床上显着的改善，该改善在I个月持续存在，但I受试者后来复发。结论：尽管在没有假治疗组的情况下，我们有一部分（约四分之一）的强迫症强迫症患者似乎对rTMS对任一额叶均有反应，但我们不能排除这是安慰剂反应的可能性。这种治疗方法值得进一步研究，以更好地确定其功效并检查最佳反应参数。

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