Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder

Ozdemir Pinar Guzel; Boysan Murat; Smolensky Michael H.; Selvi Yavuz; Aydin Adem; Yilmaz Ekrem

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Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder

机译：Venlafaxine单独与Venlafaxine加上强光疗法联合治疗严重抑郁症的比较

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Objective: Phototherapy, ie, bright light therapy, is an effective and safe treatment of major depressive disorder (MDD). It exerts rapid mood-elevating activity, similar to antidepressant medications, most likely mediated through both monoaminergic and circadian system melatonergic mechanisms. We assessed the efficiency of bright light therapy as an adjuvant treatment to antidepressant pharmacotherapy in patients with severe MDD randomized by Hamilton Depression Rating Scale (HDRS) score to either (1) 150 mg venlafaxine hydrochloride daily at 7: 00 am or (2) 150 mg venlafaxine plus 60-minute light of 7000 lux the initial week of clinical management (venlafaxine + bright light therapy) daily at 7: 00 am.

机译：目的：光疗法，即强光疗法，是一种有效且安全的治疗重度抑郁症的方法。它具有与抗抑郁药类似的快速情绪提升活动，最有可能通过单胺能和昼夜节律性黑素能机制介导。我们通过汉密尔顿抑郁量表（HDRS）评分将重度MDD患者随机分配为（1）150 mg盐酸文拉法辛每天7：00或（2）150，评估强光疗法作为抗抑郁药物疗法辅助治疗的有效性在临床治疗的最初一周（文拉法辛+强光疗法）每天早上7：00毫克文拉法辛加60分钟的7000 lux光照。

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《The journal of clinical psychiatry》 |2015年第5期|共10页
作者
Ozdemir Pinar Guzel; Boysan Murat; Smolensky Michael H.; Selvi Yavuz; Aydin Adem; Yilmaz Ekrem;
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正文语种 eng
中图分类精神病学;
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1. Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder [J] . Adem Aydin, Ekrem Yilmaz, Michael H. Smolensky, Primary care companion to the journal of clinical psychiatry . 2015,第5期

机译：Venlafaxine单独与Venlafaxine加强光疗法联合治疗严重抑郁症的比较
2. Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder [J] . Adem Aydin, Ekrem Yilmaz, Michael H. Smolensky, Primary care companion to the journal of clinical psychiatry . 2015,第5期

机译：Venlafaxine单独与Venlafaxine加强光疗法联合治疗严重抑郁症的比较
3. Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder [J] . Ozdemir Pinar Guzel, Boysan Murat, Smolensky Michael H., The journal of clinical psychiatry . 2015,第5期

机译：Venlafaxine单独与Venlafaxine加上强光疗法联合治疗严重抑郁症的比较
4. Toward the Precision Medicine for a Psychiatric Disorder: Light Therapy for Major Depressive Disorder with Neuroimaging Validation [C] . Fan-pei Gloria Yang, Wei-cheng Chao, Sung-wei Chen International Conference on Biomedical and Health Informatics . 2020

机译：对精神疾病进行精密药物：对神经影像学验证的主要抑郁障碍的光疗
5. Identification of risk and protective factors among adults with bipolar disorder with major depressive disorder comparison group [D] . Barber, Christina L. 2008

机译：患有重度抑郁症的双相情感障碍成年人的危险因素和保护因素的比较组
6. Milnacipran and venlafaxine at flexible doses (up to 200 mg/day) in the outpatient treatment of adults with moderate-to-severe major depressive disorder: a 24-week randomized double-blind exploratory study [O] . Jean-Pierre Olié, David Gourion, Agnès Montagne, 2010

机译：成人中度至重度抑郁症患者的门诊治疗中米那普仑和文拉法辛灵活剂量（最高200毫克/天）：一项为期24周的随机双盲探索性研究
7. PMH19 A COMPARISON OF TOTAL DIRECT MEDICAL COSTS TO MANAGED CARE OF ESCITALOPRAM VERSUS VENLAFAXINE XR TREATMENT IN MAJOR DEPRESSIVE DISORDER [O] . Erder MH, Wang C, Jonas JM 2007

机译：PMH19对严重抑郁症患者经皮穿刺与文拉法辛XR治疗的直接护理总费用的比较

Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder

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