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首页> 外文期刊>The Journal of dermatology >The successful use of topical tacrolimus treatment for a chronic actinic dermatitis patient with complications of idiopathic leukopenia.
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The successful use of topical tacrolimus treatment for a chronic actinic dermatitis patient with complications of idiopathic leukopenia.

机译：他克莫司局部治疗成功用于患有特发性白细胞减少症的慢性光化性皮炎患者。

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摘要

Chronic actinic dermatitis (CAD) is a photosensitivity disorder marked by severe eczematous lesions on exposed areas. Although associations with contact dermatitis, atopic dermatitis, and human immunodeficiency virus (HIV) have been suggested, its pathogenesis remains unknown. CAD is often refractory, and systemic administration of cyclosporin A has been the treatment of choice. Recently, topical tacrolimus therapy has been reported to be effective. We report the efficacy of topical tacrolimus treatment in a CAD patient who also had the complication of idiopathic leukopenia. A phototest showed marked suppression of erythema formation in the skin pre-treated with tacrolimus before UVB radiation but not in the skin treated after the irradiation. Therefore, it is suggested that tacrolimus may prevent UV-B induced erythema by suppressing a very early phase of the inflammatory process in CAD.
机译：慢性光化性皮炎（CAD）是一种光敏性疾病，其特征是暴露区域出现严重的湿疹性病变。尽管已提出与接触性皮炎，特应性皮炎和人类免疫缺陷病毒（HIV）的关联，但其发病机理仍然未知。 CAD通常是难治性的，而环孢菌素A的全身给药已成为治疗的选择。最近，已报道局部他克莫司疗法是有效的。我们报告局部他克莫司治疗在CAD患者中的疗效，该患者还患有特发性白细胞减少症。光电测试显示在UVB辐射之前用他克莫司预处理的皮肤中明显抑制了红斑形成，但在辐射后未抑制。因此，建议他克莫司可以通过抑制CAD中炎症过程的早期来预防UV-B引起的红斑。

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