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首页> 外文期刊>The Journal of dermatology >Variation in the COL29A1 gene in German patients with atopic dermatitis, asthma and chronic obstructive pulmonary disease.
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Variation in the COL29A1 gene in German patients with atopic dermatitis, asthma and chronic obstructive pulmonary disease.

机译：德国特应性皮炎，哮喘和慢性阻塞性肺疾病患者的COL29A1基因变异。

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摘要

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dry, itchy skin lesions that usually presents in early childhood.1 The prevalence is approximately 5-15% in Western Europe.2 AD belongs to the group of allergic disorders also including food allergy, allergic rhinitis and asthma. It is supposed to be a multifactorial disorder influenced by environmental as well as genetic factors.3 A genome-wide screen in European families reported linkage to a region on chromosome 3q21.4 Recently, Soderhall et al.5 further investigated this region in a family-based association analysis using microsatellite markers and single nucleotide polymorphisms (SNP).
机译：特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征在于干燥，发痒的皮肤病变，通常出现在儿童早期。1在西欧，患病率约为5-15％。2AD属于过敏性疾病，其中包括食物过敏，过敏性鼻炎和哮喘。据推测，这是受环境和遗传因素影响的多因素疾病。3欧洲家庭的全基因组筛选报道与染色体3q21.4的一个区域有联系。最近，Soderhall等人5进一步研究了该区域的这一区域。微卫星标记和单核苷酸多态性（SNP）的基于基因的关联分析。

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