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首页> 外文期刊>The Journal of dermatology >Development of psoriasis 10 years after allogeneic hematopoietic cell transplantation from non-psoriatic donor. Further evidences for genetics and immunopathogenesis of psoriasis
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Development of psoriasis 10 years after allogeneic hematopoietic cell transplantation from non-psoriatic donor. Further evidences for genetics and immunopathogenesis of psoriasis

机译：非牛皮癣供体同种异体造血细胞移植后10年牛皮癣的发展。银屑病的遗传学和免疫发病机制的进一步证据

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摘要

The exact cause of psoriasis is unclear, but it is thought to be a multifactorial disease triggered by both genetic and environmental factors. Due to the therapeutic success of cyciosporin A, a T-ceil-targeted immunosuppressant agent, psoriasis has been thought to be a T-cell-mediated inflammatory skin disease. Currently, psoriasis is regarded as an immune-mediated skin disease based on both genetic and environmental factors. A 34-year-old Japanese woman (height, 157 cm; body-weight, 55 kg; body mass index, 22.3; non-smoker) visited our hospital with skin lesions which had begun on her hands and gradually spread to the trunk, extremities and scalp. She underwent allogeneic peripheral blood stem cell transplantation (PBSCT) at the age of 24 years, which was 3 years into the diagnosis of non-Hodgkin's lymphoma (diffuse small cell type). Allo-PBSCT was performed from a human leukocyte antigen (HLA)-identical -A2, -A24, -B39, -B52, -C7 negative brother. Her family history was unremarkable; her brother had no psoriasis. Cyciosporin and methotrexate were given for graft-ver-sus-host disease (GVHD) prophylaxis. On day 12, she had complete engraftment of donor cells and complete remission of lymphoma. There were no symptoms of acute GVHD.
机译：牛皮癣的确切病因尚不清楚，但被认为是由遗传和环境因素共同引发的多因素疾病。由于环孢菌素A（一种T细胞靶向的免疫抑制剂）的治疗成功，银屑病被认为是一种T细胞介导的炎性皮肤病。当前，基于遗传和环境因素，牛皮癣被认为是免疫介导的皮肤疾病。一名34岁的日本女性（身高157厘米;体重55公斤;体重指数22.3;不吸烟）到我们医院就诊，皮肤上的病变已经开始，并逐渐扩散到躯干，四肢和头皮。她于24岁接受异体外周血干细胞移植（PBSCT），距诊断非霍奇金淋巴瘤（弥漫性小细胞类型）仅3年。从人白细胞抗原（HLA）-相同的-A2，-A24，-B39，-B52，-C7阴性兄弟进行Allo-PBSCT。她的家族史并不多见。她的兄弟没有牛皮癣。给予环孢菌素和甲氨蝶呤用于预防移植物抗宿主病（GVHD）。在第12天，她已完全植入供体细胞并完全缓解了淋巴瘤。没有急性GVHD的症状。

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