Patients with malignant lymphoma may develop non-infectious qranulomas in both involved and non-involved organs, including the skin and lymph nodes. Cutaneous granulomas in the setting of malignant lymphoma are divided into two types. The first type involves cutaneous granuloma without lymphoma cells and consists of sarcoid-like granulomas or other granulomatous skin processes. The second type is characterized by granulomatous infiltrates admixed with lymphoma cells within specific skin lesions of malignant lymphoma. A granulomatous variant of mycosis fungoides (MF) is the most typical example.2 Fewer than 100 cases of granulomatous MF have been reported, and the CD8~+ phenotype is extremely rare.
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