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首页> 外文会议>Mexican Symposium on Medical Physics >Characterization of Unconventional Electron Fields for the Treatment of Mycosis Fungoides Using the Total Skin Irradiation Technique
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Characterization of Unconventional Electron Fields for the Treatment of Mycosis Fungoides Using the Total Skin Irradiation Technique

机译：用总皮肤辐射技术表征用于治疗霉菌菌霉菌的非传民电子场

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Mycosis fungoides is a cutaneous lymphoma that accounts for 2-3% of all lymphomas. Several clinical studies have demonstrated the effectiveness of TSEBT (Total Skin Electron Beam Therapy) in patients with mycosis fungoides. It is important to develop this technique and make it available to a larger number of patients in Mexico. Because large fields for electron TSEBT are required in order to cover the entire body of the patient, beam characterization at conventional treatment distances is not sufficient and a calibration distance of 500cm or higher is required. Materials and methods:Calibration of radiochromic Gafchromic~? EBT2 film (RCF) for electrons was performed in a solid water phantom (Scanditronix Wellh?fer) at a depth of 1.4cm and a Source Axis Distance (SAD) of 100cm. A polynomial fit was applied to the calibration curve, in order to obtain the equation relating dose response with optical density. The spatial distribution is obtained in terms of percentage of the dose, placing 3×3cm samples of RCF on the acrylic screen, which is placed in front of the patient in order to obtain maximum absorbed dose on the skin, covering an area of 200×100cm~2. The Percentage Depth Dose (PDD) curve was obtained placing RCF samples at depths of 0, 1, 1.2, 1.4, 1.5, 2, 3, 4, 5, 6, 7, 8 and 9cm in the solid water phantom, irradiated with an ELEKTA SINERGY Linear Accelerator electron beam, with an energy of 6 MeV, at a Source Skin Distance (SSD) of 500cm, with 1000MU = 100Gy, with a cone of 40x40cm and gantry angle of 90°. The RCFs were scanned on a flatbed scanner (EPSON EXPRESSION 10000 XL) and the images were processed with the ImageJ program using a region of interest (ROI) of 1x1cm2. Results:The relative spatial dose distribution and the percentage depth dose for a SSD of 500±0.5cm, over an area of 200×100cm~2 was obtained, resulting to an effective maximum dose depth (Zref) for electrons of 1.4±0.05cm. Using the same experimental data, horizontal and vertical beam profiles were also graphed, showing a horizontal symmetry of ±035%, horizontal flatness of ±3.62%, vertical symmetry of ±2.1% and vertical flatness of ±14.2%. Conclusions:The electron beam was characterized and the data obtained were useful to determine the spatial dose distribution to a SSD of 500±0.5cm, in an area of 200x100cm2. Dose profiles were obtained both horizontally and vertically, thus allowing to assess electron beam symmetry and flatness. PDD analysis up to a depth of 9±0.05cm, has made possible to establish the depth of electron penetration, assuring an only skin irradiation treatment.
机译：蕈菌菌诱导是一种皮肤淋巴瘤，占所有淋巴瘤的2-3％。几项临床研究表明，霉菌菌诱导患者的TSEBT（总皮带束治疗）的有效性。开发这种技术很重要，并使其在墨西哥的更多患者中可用。因为用于覆盖患者的整个身体的电子TESEBT的大场，所以在常规处理距离处的光束表征不足并且需要校准距离或更高的校准距离。材料与方法：校准放射刻度的Gafchromic〜？电子的EBT2膜（RCF）在固体水体模型（Scanditronix Wellh？FER）中进行，深度为1.4cm，源轴距离（令人难过）为100cm。将多项式配合施加到校准曲线上，以获得具有光密度的等式与光密度相关的等式。在剂量的百分比上获得空间分布，将3×3cm的RCF样品放置在丙烯酸屏上，该丙烯酸筛放置在患者的前面，以便获得皮肤上的最大吸收剂量，覆盖面积为200× 100cm〜2。获得百分比深度剂量（PDD）曲线在固体水幻影中将RCF样品放置在0,1,1.2,1.4,1.5,2,3,4,5,6,7,8和9cm的深度中，用ELEKTA Sinergy线性加速器电子束，能量为6 MeV，在500cm的源皮肤距离（SSD），1000mu = 100Gy，锥形为40x40cm，龙门杆角度为90°。在平板扫描仪（EPSON表达式10000 XL）上扫描RCFS并使用1x1cm2的感兴趣区域（ROI）与图像进行处理。结果：获得的相对空间剂量分布和SSD的百分比深度剂量为500±0.5cm，在面积为200×100cm〜2面积，导致电子的最大剂量深度（Zref）为1.4±0.05cm 。使用相同的实验数据，还绘制了水平和垂直光束型材，显示±035％，水平平整度为±3.62％的水平对称，±2.1％垂直对称，垂直平整度为±14.2％。结论：电子束的特征在于，所获得的数据可用于将空间剂量分布确定为500±0.5cm的SSD，在200×10CM2的面积中。剂量曲线在水平和垂直地获得，从而允许评估电子束对称和平坦度。 PDD分析高度为9±0.05厘米，已经实现了电子穿透深度，确保了唯一的皮肤照射处理。

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