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首页> 外文期刊>The Journal of dermatology >Merkel cell carcinoma associated with stable chronic hemodialysis: A report of two cases
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Merkel cell carcinoma associated with stable chronic hemodialysis: A report of two cases

机译：稳定的慢性血液透析相关的默克尔细胞癌：2例报道

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摘要

Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous malignancy associated with the Merkel cell polyomavirus (MCPyV). Multiple studies have shown that the incidence of MCC is higher among immunocompromised individuals than among the general population. In fact, immunosuppressed individuals account for approximately 10% of the MCC patient population. In this report, we describe two cases of MCPyV-related MCC in Japanese patients on hemodialysis. In both the cases, MCC was present on the face. Both cellular and humoral immunities have been shown to be decreased in uremic patients, and dialysis patients have a high risk of viral-mediated cancers, including human papillomavirus-associated cancers. Immune dysfunction related to uremia and dialysis may be associated with a high risk of developing MCC.
机译：默克尔细胞癌（MCC）是与默克尔细胞多瘤病毒（MCPyV）相关的罕见但侵袭性皮肤恶性肿瘤。多项研究表明，免疫功能低下的个体中MCC的发生率高于一般人群。实际上，免疫抑制的个体约占MCC患者总数的10％。在本报告中，我们描述了日本2例接受血液透析的MCPyV相关MCC病例。在这两种情况下，脸上都有MCC。尿毒症患者的细胞和体液免疫均已降低，而透析患者的病毒介导的癌症（包括与人乳头瘤病毒相关的癌症）的风险较高。与尿毒症和透析有关的免疫功能障碍可能与发生MCC的高风险有关。

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