...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of dermatology >Three cases of pigmented cosmetic dermatitis-like eruptions associated with primary Sjogren's syndrome or anti-SSA antibody
【24h】

Three cases of pigmented cosmetic dermatitis-like eruptions associated with primary Sjogren's syndrome or anti-SSA antibody

机译：三例与原发性干燥综合征或抗SSA抗体有关的色素性皮肤炎

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pigmented cosmetic dermatitis-like (Riehl's melanosis-like) pigmentation was reported in three of 27 patients with primary Sjogren's syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjogren's syndrome or anti-SSA antibody and possible associations with specific types of human leukocyte antigen (HLA) and infiltrating lymphocytes. These middle-aged Japanese women had reticular facial pigmentation and histopathological examination revealed interface dermatitis, melanophages, and dense lymphocytic infiltration around hair follicles and sweat ducts. HLA typing revealed common antigenic equivalents or genetic typing of HLA-A2, DR52, DPA1(02:02) and DPB1(05:01). Immunohistochemical staining revealed major subsets of T cells to be CD8 and CD45RO. Some Foxp3- and few IL17-positive cells were found in strong contrast to the major CD4 subset of infiltrated T cells in annular erythema associated with Sjogren's syndrome. Apparently, our patients' pigmentation represented a specific etiology associated with primary Sjogren's syndrome or anti-SSA antibody.
机译：在原发性干燥综合征27例中，有3例报告了色素性化妆品性皮炎（Riehl's黑色素样）色素沉着。但是这种喷发的案例报道很少。我们描述了与原发性干燥综合征或抗SSA抗体相关的此类爆发的三例，以及与特定类型的人类白细胞抗原（HLA）和浸润淋巴细胞的可能关联。这些日本中年妇女面部网状色素沉着，组织病理学检查发现界面皮炎，黑色素细胞以及毛囊和汗管周围密集的淋巴细胞浸润。 HLA分型揭示了HLA-A2，DR52，DPA1（02:02）和DPB1（05:01）的常见抗原等同物或基因分型。免疫组织化学染色显示T细胞的主要亚群为CD8和CD45RO。在与干燥综合征相关的环形红斑中，发现一些Foxp3细胞和少量IL17阳性细胞与浸润T细胞的主要CD4亚群形成强烈反差。显然，我们患者的色素沉着代表了与原发性干燥综合征或抗SSA抗体相关的特定病因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号