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首页> 外文期刊>The Journal of dermatology >Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3
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Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3

机译：糜烂性口腔扁平苔藓2例，其自身抗体具有去氨胆红素3

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Oral lichen planus (OLP) is a chronic inflammatory disorder of the oral mucosa of unknown etiology. Clinically, the erosive type of OLP (erosive OLP) can show features similar to those of pemphigus vulgaris (PV), an autoimmune blistering disorder in which desmoglein (Dsg) 3 is targeted. In addition to clinical and histopathological findings, immunological studies, including direct immunofluorescence (IF), indirect IF and enzyme-linked immunosorbent assay (ELISA) that detect autoantibodies to Dsg3, are helpful in differentiating erosive OLP from PV. Here, we show two cases of erosive OLP with autoantibodies to Dsg3. Patient 1 was a 68-year-old woman with chronic erosions of the oral mucosa, in which elevated levels of immunoglobulin (Ig)G autoantibodies to Dsg1 and Dsg3 were detected by ELISA. Patient 2 was an 85-year-old woman with white striae with erosions on the lateral sides of the buccal mucosa with elevated levels of IgG autoantibodies to Dsg3 detected by ELISA. Histopathological findings from both cases showed lichenoid dermatitis, and both direct and indirect IF showed no tissue-bound IgG autoantibodies. From these findings, the diagnosis of erosive OLP was made. Immunological assays revealed both cases to have IgG-directing calcium-independent linear epitopes on Dsg3, which are suggestive of non-pathogenic autoantibodies. In addition, autoantibodies to Dsg3 in patient 2 reacted with a prosequence-possessing precursor form of Dsg3 but not with the mature form of the molecule. The present study suggests that erosive OLP may develop anti-Dsg3 autoantibodies, which should be carefully assessed.
机译：口腔扁平苔藓（OLP）是一种病因不明的慢性口腔粘膜炎性疾病。在临床上，侵蚀性类型的OLP（侵蚀性OLP）可以显示出与寻常性天疱疮（PV）类似的特征，寻常性天疱疮（PV）是一种针对自身免疫性水疱性疾病，其中以桥粒芯蛋白（Dsg）3为靶点。除了临床和组织病理学发现外，免疫学研究（包括直接免疫荧光（IF），间接IF和酶联免疫吸附测定（ELISA））可检测Dsg3的自身抗体，有助于区分侵蚀性OLP和PV。在这里，我们显示了带有Dsg3自身抗体的2种侵蚀性OLP病例。患者1是一名68岁的女性，患有口腔粘膜的慢性糜烂，其中通过ELISA检测到针对Dsg1和Dsg3的免疫球蛋白（Ig）G自身抗体水平升高。患者2是一名85岁的女性，有白色条纹，在颊粘膜的侧面有糜烂，通过ELISA检测到的针对Dsg3的IgG自身抗体水平升高。两种病例的组织病理学结果均显示为类苔藓样皮炎，直接和间接IF均未见组织结合的IgG自身抗体。从这些发现，诊断出侵蚀性OLP。免疫学分析显示，这两个病例在Dsg3上均具有IgG定向的钙非依赖性线性表位，提示非病原性自身抗体。另外，患者2中针对Dsg3的自身抗体与具有顺序列的Dsg3的前体形式反应，但与分子的成熟形式不反应。本研究表明，侵蚀性OLP可能会产生抗Dsg3自身抗体，应仔细评估。

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