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首页> 外文期刊>The Journal of arthroplasty >The Efficacy of Combined Use of Intraarticular and Intravenous Tranexamic Acid on Reducing Blood Loss and Transfusion Rate in Total Knee Arthroplasty
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The Efficacy of Combined Use of Intraarticular and Intravenous Tranexamic Acid on Reducing Blood Loss and Transfusion Rate in Total Knee Arthroplasty

机译：关节内和静脉内氨甲环酸联合使用对减少全膝关节置换术的失血量和输血速度的功效

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摘要

The purpose of this study is to investigate the effect of preoperative intravenous (IV) and intraoperative topical administration of tranexamic acid (TXA) in total knee arthroplasty (TKA). A total of 120 patients were and randomly allocated to either topical group, combined group, or control group. The mean total blood loss was lower in the combined and topical groups (705 mL and 579 mL, respectively) in comparison with control group (949 mL, P < 0.001). There was a significant difference in transfusion rate among groups (P = 0.009). The postoperative hemoglobin drop and total drain amount were significantly less in the combined group compared to other groups. In conclusion, combining preoperative IV injection and topical administration of TXA can effectively reduce blood loss and transfusion rate. (C) 2014 Elsevier Inc. All rights reserved.
机译：这项研究的目的是调查术前静脉（IV）和术中局部施用氨甲环酸（TXA）在全膝关节置换术（TKA）中的作用。总共120例患者被随机分配到局部组，联合组或对照组。与对照组（949 mL，P <0.001）相比，联合组和局部组的平均总失血量较低（分别为705 mL和579 mL）。各组之间的输血率存在显着差异（P = 0.009）。与其他组相比，合并组的术后血红蛋白下降和总引流量明显减少。综上所述，术前静脉注射与TXA局部给药相结合可以有效减少失血和输血率。 （C）2014 Elsevier Inc.保留所有权利。

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