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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Maternal circulating levels of irisin in intrahepatic cholestasis of pregnancy
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Maternal circulating levels of irisin in intrahepatic cholestasis of pregnancy

机译：妊娠肝内胆汁淤积症的孕妇体内鸢尾素水平

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Objective: Intrahepatic cholestasis of pregnancy (ICP), the most common liver disease in pregnancy, is characterized by elevated serum total bile acid levels and pruritus. It has become clear that bile acids are no longer labeled as simple detergent-like molecules, but also represent complex hormonal metabolic regulators. ICP has also been associated with increased incidence rates of gestational diabetes mellitus. Irisin is a newly discovered myokine that is able to regulate glucose and lipid levels, thus improving insulin sensitivity. In this study, maternal serum irisin levels were analyzed in order to provide a new perspective on the pathogenesis of ICP.Materials and methods: In this controlled cross-sectional study, 58 consecutive pregnant women with ICP (30 with mild and 28 with severe disease) and 30 healthy women with uncomplicated pregnancies (as the control group) were examined. The maternal irisin, fasting blood glucose, fasting insulin and homeostatic model assessment of insulin resistance levels of the two groups were compared.Results: Serum irisin levels were significantly higher in the severe ICP group than in the mild ICP and control groups (p=0.005 and p<0.001, respectively). At the best cut-off level of 908.875pg/ml, irisin accurately predicted ICP [AUC=0.827 (95% CI: 0.745-0.909; p<0.001)] with sensitivity and specificity rates of 72.5 and 86.8%, respectively. There was a significant negative correlation between irisin and fasting blood glucose levels (r=-0.399; p=0.021).Conclusion: The results of this study indicate that serum irisin levels were significantly higher in women with ICP compared to healthy pregnant controls. However, it is difficult to infer whether high irisin level is a cause or effect of ICP.
机译：目的：妊娠肝内胆汁淤积症（ICP）是妊娠中最常见的肝脏疾病，其特征在于血清总胆汁酸水平升高和瘙痒。已经清楚的是，胆汁酸不再被标记为简单的洗涤剂样分子，而是代表复杂的激素代谢调节剂。 ICP还与妊娠糖尿病的发生率增加有关。鸢尾素是一种新发现的肌肉因子，能够调节葡萄糖和脂质水平，从而改善胰岛素敏感性。在这项研究中，分析了孕妇的血清虹膜素水平，以便为ICP的发病机理提供新的视角。材料和方法：在这项对照研究中，连续58例ICP孕妇（30例轻症和28例重症患者） ）和30例无并发症妊娠的健康女性（作为对照组）。比较了两组患者的孕妇虹膜素，空腹血糖，空腹胰岛素和体内稳态模型对胰岛素抵抗的评估结果。结果：重度ICP组的血清虹膜素水平明显高于轻度ICP组和对照组（p = 0.005）。和p <0.001）。以908.875pg / ml的最佳截止水平，虹膜素可准确预测ICP [AUC = 0.827（95％CI：0.745-0.909; p <0.001）]，灵敏度和特异度分别为72.5和86.8％。虹膜素与空腹血糖水平之间存在显着的负相关（r = -0.399; p = 0.021）。结论：这项研究的结果表明，与健康孕妇相比，ICP患者的血清虹膜素水平明显更高。但是，很难推断高虹膜素水平是ICP的原因还是结果。

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